Re-irradiation in recurrent malignant glioma

• Verfasst von: Niyazi, Karim-Maximilian [VerfasserIn]
• Verfasst von: Büsing, Karen-Anett [VerfasserIn]
• Titel: Re-irradiation in recurrent malignant glioma
• Titelzusatz: prognostic value of [18F]FET-PET
• Verf.angabe: Maximilian Niyazi, Nathalie Jansen, Ute Ganswindt, Silke Birgit Schwarz, Julia Geisler, Oliver Schnell, Karen Büsing, Sabina Eigenbrod, Christian la Fougère, Claus Belka
• Umfang: 7 S.
• Fussnoten: Gesehen am 16.08.2018 ; Im Titel ist "18" in [18F]FET-PET hochgestellt
• Titel Quelle: Enthalten in: Journal of neuro-oncology
• Jahr Quelle: 2012
• Band/Heft Quelle: 110(2012), 3, S. 389-395
• ISSN Quelle: 1573-7373
• DOI: doi:10.1007/s11060-012-0980-7
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580122272

Abstract

The aim of the present study is to determine new positron emission tomography (PET) imaging-related factors predictive of progression-free survival as well as survival in patients with recurrent malignant glioma (MG) prior to and after re-irradiation. Fifty-six patients with recurrent MG who underwent re-irradiation treatment and pretherapeutic dynamic [18F]-fluoroethyl-l-tyrosine (FET)-PET scan were retrospectively analyzed. The prognostic value of different parameters, such as biological tumor volume, maximal tumor uptake (SUVmax/BG), mean tumor uptake (SUVmean/BG), as well as uptake kinetics, was evaluated. [18F]FET uptake kinetics was classified according to a five-point rating as category G1-2 (strongly/mainly increasing kinetics), G3 (mixed 1:1), or G4-5 (mainly/strongly decreasing kinetics). Patients within the pretherapeutic kinetic group G4-5 had significantly worse survival than the other two groups (p = 0.01). Multivariate analysis revealed that histologic grade, Karnofsky Performance Score (KPS), and kinetic group were independent significant predictors for survival after re-irradiation. The uptake kinetics of [18F]FET-PET is an independent determinant of overall and to a lesser extent also progression-free survival. Thus, [18F]FET-PET kinetics may provide valuable additional prognostic information for treatment decisions.