Clinical spectrum of primary cutaneous CD30-positive anaplastic large cell lymphoma

• Verfasst von: Booken, Nina [VerfasserIn]
• Verfasst von: Goerdt, Sergij [VerfasserIn]
• Verfasst von: Klemke, Claus-Detlev [VerfasserIn]
• Titel: Clinical spectrum of primary cutaneous CD30-positive anaplastic large cell lymphoma
• Titelzusatz: an analysis of the Mannheim Cutaneous Lymphoma Registry
• Verf.angabe: Nina Booken, Sergij Goerdt, Claus-Detlev Klemke
• E-Jahr: 2012
• Jahr: 24 April 2012
• Umfang: 9 S.
• Fussnoten: The results of this paper were presented in part at the annual meeting of the German Society of Dermatology (DDG) on April 1, 2011. - Gesehen am 16.08.2018
• Titel Quelle: Enthalten in: Deutsche Dermatologische GesellschaftJournal der Deutschen Dermatologischen Gesellschaft
• Ort Quelle: Berlin : Wiley-Blackwell, 2003
• Jahr Quelle: 2012
• Band/Heft Quelle: 10(2012), 5, Seite 331-339
• ISSN Quelle: 1610-0387
• DOI: doi:10.1111/j.1610-0387.2011.07794.x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: C-ALCL
• Sach-SW: CTCL
• Sach-SW: follow-up
• Sach-SW: primary cutaneous CD30+ anaplastic large cell lymphoma
• K10plus-PPN: 1580122582

Abstract

Background: Primary cutaneous CD30+ anaplastic large cell lymphomas (C-ALCL) have indolent clinical behavior with an estimated 5-year survival rate of 95%. The clinical features and disease courses of C-ALCL identified in the lymphoma registry of Mannheim University hospital are described in the following. Patients and methods: All C-ALCL patients identified in the database were analyzed in regard to clinical picture, histology, immunohistochemistry, molecular biology, staging, therapy, follow-up, and outcome. Results: 14 C-ALCL patients were identified. The mean age was 69 years and 57% were men. Solitary skin lesions in one anatomical region were seen in 12 patients upon initial diagnosis. Two patients presented with multiple lesions at different anatomical sites. In 2 patients there was specific lymph node involvement. In one C-ALCL patient, follow-up over 17 months revealed extracutaneous infiltration. Half of the patients relapsed and 36% had multiple episodes. The majority of our patients were treated with surgical excision followed by electron beam radiotherapy. The 5-year survival rate was 93% in C-ALCL. Conclusions: The clinical presentation of C-ALCL varies. Staging procedures and a close clinical pathological correlation at initial diagnosis are essential. Due to a high rate of relapses and the possibility of developing extranodal manifestations over the course of the disease, close follow-up is recommended.