Phosphatase reactivity of a dicopper(II) complex of a patellamide derivative - possible biological functions of cyclic pseudopeptides

• Verfasst von: Comba, Peter [VerfasserIn]
• Verfasst von: Westphal, Michael [VerfasserIn]
• Titel: Phosphatase reactivity of a dicopper(II) complex of a patellamide derivative - possible biological functions of cyclic pseudopeptides
• Verf.angabe: Peter Comba, Lawrence R. Gahan, Graeme R. Hanson and Michael Westphal
• Jahr: 2012
• Umfang: 3 S.
• Fussnoten: Gesehen am 22.08.2018
• Titel Quelle: Enthalten in: Chemical communications
• Ort Quelle: Cambridge : Soc., 1965
• Jahr Quelle: 2012
• Band/Heft Quelle: 48(2012), 75, Seite 9364-9366
• ISSN Quelle: 1364-548X
• DOI: doi:10.1039/C2CC34836E
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580272630

Abstract

A possible biological function of cyclic pseudo-octapeptides is presented. The dinuclear copper(II) complex of a synthetic analogue ([Cu2(H2Pat1)(μ-OH)(OH2)2]) of the naturally occurring ascidiacyclamide is known to have a hydroxo-bridged dicopper(II) site which is able to catalytically transform CO2 into CO32−. This complex is shown here to function as a phosphatase mimic, suggesting that the so far unknown biological function of these macrocycles within the ascidians may involve phosphoester hydrolysis.