Let's burn whatever you have

• Verfasst von: Scheideler, Marcel [VerfasserIn]
• Verfasst von: Herzig, Stephan [VerfasserIn]
• Titel: Let's burn whatever you have
• Titelzusatz: mitofusin 2 metabolically re-wires brown adipose tissue
• Verf.angabe: Marcel Scheideler & Stephan Herzig
• E-Jahr: 2017
• Jahr: 24 May 2017
• Umfang: 2 S.
• Fussnoten: Gesehen am 22.08.2018
• Titel Quelle: Enthalten in: European Molecular Biology OrganizationEMBO reports
• Ort Quelle: Heidelberg : EMBO Press, 2000
• Jahr Quelle: 2017
• Band/Heft Quelle: 18(2017), 7, Seite 1039-1040
• ISSN Quelle: 1469-3178
• DOI: doi:10.15252/embr.201744341
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580277837

Abstract

Brown adipose tissue (BAT) has received enormous scientific and lay attention in the recent past as its thermogenic, energy-consuming capacities represent prime candidates for therapeutic interventions toward obesity, glucose intolerance, and diabetes even in humans. The overall positive effects of BAT activation and recruitment on systemic energy homeostasis have been largely attributed to the inherent ability of brown adipocytes to combust fatty acid and glucose energy substrates through mitochondrial uncoupling, driven by the unique expression of uncoupling protein 1 (UCP1). Two recent reports by Boutant et al and Mahdaviani et al now identify the GTPase mitofusin (Mfn) 2 as a key determinant of BAT thermogenic function that is largely independent of its previously described role in mitochondrial fusion [1,2].