Status: Bibliographieeintrag
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| Verfasst von: | Jonas, Rahul A. [VerfasserIn]  |
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| | Jonas, Jost B. [VerfasserIn] |
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| | Ellis-Behnke, Rutledge [VerfasserIn] |
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| Titel: | The spider effect |
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| Titelzusatz: | morphological and orienting classification of microglia in response to stimuli in vivo |
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| Verf.angabe: | Rahul A. Jonas, Ti-Fei Yuan, Yu-Xiang Liang, Jost B. Jonas, David K. C. Tay, Rutledge G. Ellis-Behnke |
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| E-Jahr: | 2012 |
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| Jahr: | February 21, 2012 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 22.208.2018 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 7(2012,2) Artikel-Nummer e30763, 12 Seiten |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | The different morphological stages of microglial activation have not yet been described in detail. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed: from stage 1A to 6A, the cell body size increased, the cell process number decreased, and the cell processes retracted and thickened, orienting toward the direction of the injury site; until stage 6A, when all processes disappeared. In contrast, in deactivation stages 6R to 1R, the microglia returned to the original site exhibiting a stepwise retransformation to the original morphology. Thin highly branched processes re-formed in stage 1R, similar to those in stage 1A. This reverse transformation mirrored the forward transformation except in stages 6R to 1R: cells showed multiple nuclei which were slowly absorbed. Our findings support a morphologically defined stepwise activation and deactivation of microglia cells. |
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| DOI: | doi:10.1371/journal.pone.0030763 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1371/journal.pone.0030763 |
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| | kostenfrei: Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030763 |
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| | DOI: https://doi.org/10.1371/journal.pone.0030763 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell processes |
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| | Cell staining |
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| | Central nervous system |
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| | Histology |
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| | Macrophages |
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| | Microglial cells |
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| | Olfactory bulb |
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| | Spider webs |
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| K10plus-PPN: | 1580308023 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ spider effect / Jonas, Rahul A. [VerfasserIn]; February 21, 2012 (Online-Ressource)
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