| |  Online-Ressource |
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| Verfasst von: | Santos, Edgar [VerfasserIn]  |
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| | Orakcioglu, Berk [VerfasserIn] |
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| | Kentar, Modar [VerfasserIn] |
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| | Diedler, Jennifer [VerfasserIn] |
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| | Uozumi, Yoichi [VerfasserIn] |
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| | Schöll, Michael [VerfasserIn] |
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| | Unterberg, Andreas [VerfasserIn] |
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| | Sakowitz, Oliver [VerfasserIn] |
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| Titel: | Pressure reactivity index correlates with metabolic dysfunction in a porcine model of intracerebral hemorrhage |
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| Verf.angabe: | Edgar Santos, Berk Orakcioglu, Modar M. Kentar, Jennifer Diedler, Yoichi Uozumi, Michael Schöll, Andreas Unterberg, Oliver W. Sakowitz |
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| E-Jahr: | 2012 |
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| Jahr: | 13 January 2012 |
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| Umfang: | 5 S. |
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| Fussnoten: | First online: 13 January 2012 |
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| Titel Quelle: | Enthalten in: Intracranial pressure and brain monitoring XIV |
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| Ort Quelle: | 2012 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 114(2012), Seite 363-367 |
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| ISBN Quelle: | 978-3-7091-0956-4 |
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| Abstract: | OBJECTIVE: We correlated oxygen, flow, and pressure indices of cerebrovascular reactivity (CR) with extracellular cerebral metabolite concentrations in a porcine model of intracerebral hemorrhage (ICH). METHODS: Continuous advanced multimodal monitoring including microdialysis, cerebral blood flow and P(br)O(2) probes were placed 1 cm in front of the coronal suture in the grey/white matter junction. Following a period of 1 h of monitoring, an autologous arterial ICH with defined volumes (3 mL) was induced. Pressure-, oxygen-, and flow-related autoregulation indices (PRx, ORx, and FRx) were simultaneously calculated and correlated hourly with extracellular cerebral metabolites, including glucose, lactate, pyruvate, and glutamate. RESULTS: Seventeen swine were monitored on average 12 continuous hours per animal. FRx correlated highly with ORx (0.96, P = <0.001), but values of both FRx and ORx > 0.2 did not correlate with any microdialysis metabolite. Values of PRx > 0.2 correlated highly (0.65, P < 0.001) with the lactate/pyruvate ratio, values of PRx > 0.3 correlated with glutamate (0.67, P < 0.05), the lactate/pyruvate ratio (0.60, P < 0.01), and P(br)O(2) (-0.65, P < 0.01). CONCLUSIONS: We found evidence for impaired CR in a porcine model of ICH. The findings suggest that, among other parameters of CR, positive PRx coefficients have the highest significance and could be associated with microdialysis alterations during hypoxic events. |
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| DOI: | doi:10.1007/978-3-7091-0956-4_70 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/978-3-7091-0956-4_70 |
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| | DOI: https://doi.org/10.1007/978-3-7091-0956-4_70 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Blood Pressure |
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| | Cerebral Hemorrhage |
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| | Cerebrovascular Circulation |
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| | Disease Models, Animal |
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| | Glucose |
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| | Glutamic Acid |
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| | Homeostasis |
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| | Intracranial Pressure |
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| | Lactic Acid |
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| | Metabolic Diseases |
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| | Oxygen |
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| | Pyruvic Acid |
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| | Statistics as Topic |
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| | Swine |
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| K10plus-PPN: | 1580331920 |
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| Verknüpfungen: | → Sammelwerk |
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Pressure reactivity index correlates with metabolic dysfunction in a porcine model of intracerebral hemorrhage / Santos, Edgar [VerfasserIn]; 13 January 2012 (Online-Ressource)
