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Verfasst von:Haag, Georg Martin [VerfasserIn]   i
 Byl, Anne [VerfasserIn]   i
 Jäger, Dirk [VerfasserIn]   i
 Berger, Anne Katrin [VerfasserIn]   i
Titel:Perioperative chemotherapy in elderly patients with locally advanced adenocarcinoma of the stomach and the esophagogastric junction
Titelzusatz:a retrospective cohort analysis of toxicity and efficacy at the National Center for Tumor Diseases, Heidelberg
Verf.angabe:Georg Martin Haag, Anne Byl, Dirk Jäger, Anne Katrin Berger
Jahr:2017
Umfang:8 S.
Fussnoten:Gesehen am 24.08.2018
Titel Quelle:Enthalten in: Oncology
Ort Quelle:Basel : Karger, 1967
Jahr Quelle:2017
Band/Heft Quelle:92(2017), 5, Seite 291-298
ISSN Quelle:1423-0232
Abstract:Objective: Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxic but active regimens. Methods: Using a prospectively generated database, we analyzed 63 patients aged ≥70 years undergoing perioperative chemotherapy for locally advanced esophagogastric cancer. The information included Eastern Cooperative Oncology Group (ECOG) performance status, comorbidity index, body mass index, regimen of chemotherapy, toxicity, dosage adjustments, date of surgery, application of adjuvant treatment, date of progression, and date of death. Survival times were calculated. Results: The median age was 73 years. 96.8% of the patients received an oxaliplatin-containing regimen. In 17.5% of the patients, the dosage was reduced, and treatment was previously permanently stopped in 7.9%; 80% of the patients underwent curatively intended surgery, but only 27.5% of those undergoing resection started adjuvant treatment. Major histological regression was observed in 21.6% of the patients. The median survival was 19.1 months. Significantly improved survival times were observed for patients undergoing surgery = 0.008) and for patients with a triplet therapy (= 0.004). Survival was worse for patients aged ≥75 years. Conclusion: perioperative treatment is feasible and effective in elderly patients with esophagogastric cancer.
DOI:doi:10.1159/000458531
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1159/000458531
 Volltext: https://www.karger.com/Article/FullText/458531
 DOI: https://doi.org/10.1159/000458531
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1580379427
Verknüpfungen:→ Zeitschrift

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