Brain connectivity in psychiatric imaging genetics

• Verfasst von: Tost, Heike [VerfasserIn]
• Verfasst von: Bilek, Edda [VerfasserIn]
• Verfasst von: Meyer-Lindenberg, Andreas [VerfasserIn]
• Titel: Brain connectivity in psychiatric imaging genetics
• Verf.angabe: Heike Tost, Edda Bilek, Andreas Meyer-Lindenberg
• E-Jahr: 2012
• Jahr: 1 October 2012
• Jahr des Originals: 2011
• Umfang: 11 S.
• Fussnoten: Available online 9 November 2011 ; Gesehen am 24.08.2018
• Titel Quelle: Enthalten in: NeuroImage
• Ort Quelle: Orlando, Fla. : Academic Press, 1992
• Jahr Quelle: 2012
• Band/Heft Quelle: 62(2012), 4, Seite 2250-2260
• ISSN Quelle: 1095-9572
• DOI: doi:10.1016/j.neuroimage.2011.11.007
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Connectivity
• Sach-SW: Imaging genetics
• Sach-SW: Neural networks
• Sach-SW: Psychiatric disorders
• K10plus-PPN: 1580384153

Abstract

In the past decade, imaging genetics has evolved into a highly successful neuroimaging discipline with a variety of sophisticated research tools. To date, several neural systems mechanisms have been identified that mediate genetic risk for mental disorders linked to common candidate and genome-wide-supported variants. In particular, the examination of intermediate connectivity phenotypes has recently gained increasing popularity. This paper gives an overview of the scientific methods and evidence that link indices of neural network organization to the genetic susceptibility for mental illness with a focus on the effects of candidate genes and genome-wide supported risk variants on brain structure and function.