Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy

• Verfasst von: Nikliński, Jacek [VerfasserIn]
• Verfasst von: Manegold, Christian [VerfasserIn]
• Verfasst von: Pilz, Lothar R. [VerfasserIn]
• Verfasst von: Allgayer, Heike [VerfasserIn]
• Verfasst von: Abba, Mohammed L. [VerfasserIn]
• Titel: Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy
• Titelzusatz: the Polish MOBIT project
• Verf.angabe: Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group
• E-Jahr: 2017
• Jahr: 21 June 2017
• Umfang: 9 S.
• Fussnoten: Gesehen am 27.08.2018 ; Available online 21 June 2017
• Titel Quelle: Enthalten in: Advances in medical sciences
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2006
• Jahr Quelle: 2017
• Band/Heft Quelle: 62(2017), 2, Seite 405-413
• ISSN Quelle: 1898-4002
• DOI: doi:10.1016/j.advms.2017.05.002
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biobanking
• Sach-SW: Lung Cancer
• Sach-SW: Omics
• Sach-SW: Personalized medicine
• Sach-SW: Radiomics
• K10plus-PPN: 1580403034

Abstract

Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques.