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Verfasst von:Buhr, Nicole de [VerfasserIn]   i
 Stump-Guthier, Carolin [VerfasserIn]   i
 Tenenbaum, Tobias [VerfasserIn]   i
 Schroten, Horst [VerfasserIn]   i
Titel:Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment
Verf.angabe:Nicole de Buhr, Friederike Reuner, Ariane Neumann, Carolin Stump‐Guthier, Tobias Tenenbaum, Horst Schroten, Hiroshi Ishikawa, Kristin Müller, Andreas Beineke, Isabel Hennig‐Pauka, Thomas Gutsmann, Peter Valentin‐Weigand, Christoph G. Baums, Maren von Köckritz‐Blickwede
Jahr:2017
Jahr des Originals:2016
Umfang:16 S.
Fussnoten:First published: 23 July 2016 ; Gesehen am 27.08.2018
Titel Quelle:Enthalten in: Cellular microbiology
Ort Quelle:London : Hindawi Limited, 1999
Jahr Quelle:2017
Band/Heft Quelle:19(2017,2) Artikel-Nummer e12649, 16 Seiten
ISSN Quelle:1462-5822
Abstract:Streptococcus suis is an important meningitis-causing pathogen in pigs and humans. Neutrophil extracellular traps (NETs) have been identified as host defense mechanism against different pathogens. Here, NETs were detected in the cerebrospinal fluid (CSF) of S. suis-infected piglets despite the presence of active nucleases. To study NET-formation and NET-degradation after transmigration of S. suis and neutrophils through the choroid plexus epithelial cell barrier, a previously described model of the human blood-CSF barrier was used. NETs and respective entrapment of streptococci were recorded in the “CSF compartment” despite the presence of active nucleases. Comparative analysis of S. suis wildtype and different S. suis nuclease mutants did not reveal significant differences in NET-formation or bacterial survival. Interestingly, transcript expression of the human cathelicidin LL-37, a NET-stabilizing factor, increased after transmigration of neutrophils through the choroid plexus epithelial cell barrier. In good accordance, the porcine cathelicidin PR-39 was significantly increased in CSF of piglets with meningitis. Furthermore, we confirmed that PR-39 is associated with NETs in infected CSF and inhibits neutrophil DNA degradation by bacterial nucleases. In conclusion, neutrophils form NETs after breaching the infected choroid plexus epithelium, and those NETs may be protected by antimicrobial peptides against bacterial nucleases.
DOI:doi:10.1111/cmi.12649
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1111/cmi.12649
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.12649
 DOI: https://doi.org/10.1111/cmi.12649
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1580404545
Verknüpfungen:→ Zeitschrift

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