Effects of 12-week resistance training during radiotherapy in breast cancer patients

• Verfasst von: Wiskemann, Joachim [VerfasserIn]
• Verfasst von: Schmidt, Martina [VerfasserIn]
• Verfasst von: Klassen, Oliver [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Ulrich, Cornelia [VerfasserIn]
• Verfasst von: Potthoff, Karin [VerfasserIn]
• Verfasst von: Steindorf, Karen [VerfasserIn]
• Titel: Effects of 12-week resistance training during radiotherapy in breast cancer patients
• Verf.angabe: J. Wiskemann, M.E. Schmidt, O. Klassen, J. Debus, C.M. Ulrich, K. Potthoff, K. Steindorf
• Jahr: 2017
• Jahr des Originals: 2016
• Umfang: 11 S.
• Fussnoten: First published: 05 October 2016 ; Gesehen am 27.08.2018
• Titel Quelle: Enthalten in: Scandinavian journal of medicine & science in sports
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1991
• Jahr Quelle: 2017
• Band/Heft Quelle: 27(2017), 11, Seite 1500-1510
• ISSN Quelle: 1600-0838
• DOI: doi:10.1111/sms.12777
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: chemotherapy
• Sach-SW: fitness
• Sach-SW: isokinetic
• Sach-SW: oncology
• Sach-SW: Physical activity
• Sach-SW: strength
• K10plus-PPN: 1580410235

Abstract

Exercise is considered to be an effective supportive treatment approach in breast cancer (BC) patients. We conducted a randomized controlled trial to assess the efficacy of a 12-week PRT during radiotherapy. Strength performance was assessed by maximal isokinetic peak torque (MIPT) in two different angular velocities (60°/s and 180°/s) and maximal voluntary isometric contraction for shoulder external and internal rotation, as well as for knee extension and flexion were assessed pre- and post-intervention in 146 patients randomized to PRT or a control group. Statistical analyses were based on analysis of covariance models for the individual changes from baseline to week 13. Intention-to-treat analyses showed significant between-group differences favoring the exercise group (EX) for MIPT in knee flexion and shoulder internal and external rotation (P < 0.05). Subgroup analyses showed borderline significant differences with regard to pretreatment history, revealing that pretreated chemotherapy patients tend to benefit more from PRT than patients without chemotherapy (P = 0.06). Strength gain at the operated arm was significantly higher than at the non-operated arm in EX. PRT was efficacious in increasing upper and lower limb strength in BC patients undergoing adjuvant radiotherapy. Patients with restrictions due to breast cancer-related surgery and pretreated with chemotherapy might benefit the most.