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Verfasst von:Alexandrov, Anne W. [VerfasserIn]   i
 Hacke, Werner [VerfasserIn]   i
Titel:HeadPoST
Titelzusatz:rightly positioned, or flat out wrong?
Verf.angabe:Anne W. Alexandrov, Georgios Tsivgoulis, Michael D. Hill, David S. Liebeskind, Peter Schellinger, Bruce Ovbiagele, Adam S. Arthur, Valeria Caso, Raul G. Nogueira, J. Claude Hemphill, James C. Grotta, Werner Hacke, Andrei V. Alexandrov
E-Jahr:2018
Jahr:April 11, 2018
Umfang:5 S.
Fussnoten:Gesehen am 28.08.2018 ; Published ahead of print: April 11, 2018
Titel Quelle:Enthalten in: Neurology
Ort Quelle:Philadelphia, Pa. : Wolters Kluwer, 1951
Jahr Quelle:2018
Band/Heft Quelle:90(2018), 19, Seite 885-889
ISSN Quelle:1526-632X
Abstract:Objective: To critique the Head Positioning in Stroke Trial (HeadPoST) study methods in relation to preceding research findings in an aim to clarify the potential efficacy of positioning interventions and direction for future research. Methods Head positioning research prior to the conduct of HeadPoST was reviewed by a team of international stroke experts, and methods and findings were compared to HeadPoST. Results: Methods used to select HeadPoST patients differ substantially from those used in original head positioning studies, in particular enrollment of all types of stroke. HeadPoST enrolled primarily minor strokes (median NIH Stroke Scale 4, interquartile range [IQR] 2-8) without vascular imaging confirmation of subtype; elapsed time from stroke symptom onset to the initiation of intervention was late (median 14 hours, IQR 5-35), and time from hospital admission to enrollment was delayed (median 7 hours, IQR 2-26). Intervention integrity was not reported, including ability to achieve/maintain 30° head elevation in beds lacking head elevation capabilities. Deterioration or improvement associated with the intervention is unknown as serial assessments were not completed, and the trial's 3-month outcome was powered using unrelated study data. Conclusions: The design of HeadPoST was suboptimal to measure differences produced by the intervention. Future head positioning trials in discrete patient cohorts (in particular, large vessel occlusion) with endpoints supported by pilot work are required to understand the efficacy of this simple yet potentially important intervention.
DOI:doi:10.1212/WNL.0000000000005481
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1212/WNL.0000000000005481
 Volltext: http://n.neurology.org/content/90/19/885
 DOI: https://doi.org/10.1212/WNL.0000000000005481
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1580457193
Verknüpfungen:→ Zeitschrift

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