Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration

• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Verfasst von: Neumaier, Michael [VerfasserIn]
• Verfasst von: Findeisen, Peter [VerfasserIn]
• Titel: Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration
• Verf.angabe: Jost B. Jonas, Yong Tao, Michael Neumaier, Peter Findeisen
• E-Jahr: 2012
• Jahr: 10 April 2012
• Umfang: 8 S.
• Fussnoten: Gesehen am 28.08.2018
• Titel Quelle: Enthalten in: Acta ophthalmologica
• Ort Quelle: Oxford : Blackwell, 2008
• Jahr Quelle: 2012
• Band/Heft Quelle: 90(2012), 5, Seite e381-e388
• ISSN Quelle: 1755-3768
• DOI: doi:10.1111/j.1755-3768.2012.02414.x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cytokines
• Sach-SW: epithelial growth factor
• Sach-SW: exudative age-related macular degeneration
• Sach-SW: intercellular adhesion molecule-1
• Sach-SW: monocyte chemoattractant protein-1
• K10plus-PPN: 1580460372

Abstract

Abstract. Purpose: To measure the concentration of cytokines in the aqueous humour of eyes with exudative age-related macular degeneration (AMD). Methods: The clinical interventional study included a study group of 18 patients with exudative AMD and a control group of 20 patients undergoing routine cataract surgery. Age did not vary significantly (p = 0.36) between study group (80.8 ± 6.4 years) and control group (77.0 ± 9.9 years), nor did gender (p = 0.75). During the interventions, aqueous humour samples were obtained, in which the concentration of cytokines was measured using a solid-phase chemiluminescence immunoassay. Macular thickness was measured by optical coherence tomography (OCT). Results: In the study group as compared to the control group, significantly higher concentrations were measured for epithelial growth factor (EGF) (p = 0.017), human growth factor (HGF) (p = 0.048), intercellular adhesion molecule-1 (ICAM1) (p = 0.028), interleukin 12p40 (IL12p40) (p = 0.009), interleukin 1a2 (IL1a2) (p = 0.01), interleukin 3 (IL3) (p = 0.02), interleukin 6 (IL6) (p = 0.006), interleukin 8 (IL8) (p = 0.02), monocyte chemoattractant protein-1 (MCP-1) (p = 0.048), monokine induced by interferon gamma (MIG) (p = 0.016), matrix metalloproteinase 9 (MMP9) (p = 0.004) and plasminogen activator inhibitor 1 (PAI1) (p = 0.006). Macular thickness was significantly associated with the concentrations of EGF (p = 0.001), HGF (p = 0.02), ICAM1 (p = 0.001), interleukin 12p40 (p = 0.006), IL 1a2 (p = 0.002), MIG (p = 0.001), MMP9 (p < 0.001) and PAI1 (p = 0.01). Interleukin 6 and MCP-1 showed significant associations with the height of retinal pigment epithelium detachment. Conclusions: Numerous cytokines are associated with the presence and the amount of exudative AMD.