| |  Online-Ressource |
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| Verfasst von: | Jin, Yinhua [VerfasserIn]  |
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| | Patel, Parthive H. [VerfasserIn] |
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| | Kohlmaier, Alexander [VerfasserIn] |
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| | Pavlović, Bojana [VerfasserIn] |
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| | Zhang, Chenge [VerfasserIn] |
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| | Edgar, Bruce [VerfasserIn] |
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| Titel: | Intestinal stem cell pool regulation in drosophila |
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| Verf.angabe: | Yinhua Jin, Parthive H. Patel, Alexander Kohlmaier, Bojana Pavlovic, Chenge Zhang, Bruce A. Edgar |
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| E-Jahr: | 2017 |
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| Jahr: | 4 May 2017 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 29.08.2018 ; Available online 4 May 2017 |
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| Titel Quelle: | Enthalten in: Stem cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2013 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 8(2017), 6, Seite 1479-1487 |
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| ISSN Quelle: | 2213-6711 |
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| Abstract: | Summary Intestinal epithelial renewal is mediated by intestinal stem cells (ISCs) that exist in a state of neutral drift, wherein individual ISC lineages are regularly lost and born but ISC numbers remain constant. To test whether an active mechanism maintains stem cell pools in the Drosophila midgut, we performed partial ISC depletion. In contrast to the mouse intestine, Drosophila ISCs failed to repopulate the gut after partial depletion. Even when the midgut was challenged to regenerate by infection, ISCs retained normal proportions of asymmetric division and ISC pools did not increase. We discovered, however, that the loss of differentiated midgut enterocytes (ECs) slows when ISC division is suppressed and accelerates when ISC division increases. This plasticity in rates of EC turnover appears to facilitate epithelial homeostasis even after stem cell pools are compromised. Our study identifies unique behaviors of Drosophila midgut cells that maintain epithelial homeostasis. |
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| DOI: | doi:10.1016/j.stemcr.2017.04.002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S221367111730156X |
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| | kostenfrei: Volltext: http://dx.doi.org/10.1016/j.stemcr.2017.04.002 |
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| | DOI: https://doi.org/10.1016/j.stemcr.2017.04.002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Epithelial turnover |
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| | Intestinal stem cell |
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| | Midgut |
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| | Neutral drift |
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| | Stem cell behavior |
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| | Stem cell pool |
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| K10plus-PPN: | 1580488889 |
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| Verknüpfungen: | → Zeitschrift |
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Intestinal stem cell pool regulation in drosophila / Jin, Yinhua [VerfasserIn]; 4 May 2017 (Online-Ressource)
