Broad-spectrum agents for flaviviral infections

• Verfasst von: Boldescu, Veaceslav [VerfasserIn]
• Verfasst von: Behnam, Mira A. M. [VerfasserIn]
• Verfasst von: Klein, Christian D. [VerfasserIn]
• Titel: Broad-spectrum agents for flaviviral infections
• Titelzusatz: dengue, Zika and beyond
• Verf.angabe: Veaceslav Boldescu, Mira A.M. Behnam, Nikos Vasilakis, Christian D. Klein
• Umfang: 22 S.
• Fussnoten: Gesehen am 29.08.2018
• Titel Quelle: Enthalten in: Nature reviews / Drug discovery
• Jahr Quelle: 2017
• Band/Heft Quelle: 16(2017), 8, S. 565-586
• ISSN Quelle: 1474-1784
• DOI: doi:10.1038/nrd.2017.33
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580491081

Abstract

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis. Numerous compounds with broad-spectrum antiviral activity have already been identified by target-specific or phenotypic assays. For other compounds, broad-spectrum activity can be anticipated because of their mode of action and molecular targets.