| |  Online-Ressource |
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| Verfasst von: | Augustin, Iris [VerfasserIn]  |
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| | Goidts, Violaine [VerfasserIn] |
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| | Kerr, Grainne [VerfasserIn] |
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| | Radlwimmer, Bernhard [VerfasserIn] |
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| | Hartmann, Christian [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| Titel: | The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
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| Verf.angabe: | Iris Augustin, Violaine Goidts, Angelika Bongers, Grainne Kerr, Gordon Vollert, Bernhard Radlwimmer, Christian Hartmann, Christel Herold-Mende, Guido Reifenberger, Andreas von Deimling, Michael Boutros |
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| Jahr: | 2012 |
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| Umfang: | 14 S. |
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| Fussnoten: | Published online 07.12.2011 ; Gesehen am 29.08.2018 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2009 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 4(2012), 1, Seite 38-51 |
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| ISSN Quelle: | 1757-4684 |
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| Abstract: | Malignant astrocytomas are highly aggressive brain tumours with poor prognosis. While a number of structural genomic changes and dysregulation of signalling pathways in gliomas have been described, the identification of biomarkers and druggable targets remains an important task for novel diagnostic and therapeutic approaches. Here, we show that the Wnt-specific secretory protein Evi (also known as GPR177/Wntless/Sprinter) is overexpressed in astrocytic gliomas. Evi/Wls is a core Wnt signalling component and a specific regulator of pan-Wnt protein secretion, affecting both canonical and non-canonical signalling. We demonstrate that its depletion in glioma and glioma-derived stem-like cells led to decreased cell proliferation and apoptosis. Furthermore, Evi/Wls silencing in glioma cells reduced cell migration and the capacity to form tumours in vivo. We further show that Evi/Wls overexpression is sufficient to promote downstream Wnt signalling. Taken together, our study identifies Evi/Wls as an essential regulator of glioma tumourigenesis, identifying a pathway-specific protein trafficking factor as an oncogene and offering novel therapeutic options to interfere with the aberrant regulation of growth factors at the site of production. |
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| DOI: | doi:10.1002/emmm.201100186 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1002/emmm.201100186 |
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| | DOI: https://doi.org/10.1002/emmm.201100186 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis. - 2012 |
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| Sach-SW: | Animals |
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| | Apoptosis |
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| | Brain Neoplasms |
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| | Cell Cycle Checkpoints |
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| | Cell Line, Tumor |
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| | Cell Movement |
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| | Cell Transformation, Neoplastic |
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| | Glioma |
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| | Humans |
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| | Interleukins |
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| | Intracellular Signaling Peptides and Proteins |
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| | Mice |
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| | Mice, Nude |
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| | Receptors, G-Protein-Coupled |
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| | RNA Interference |
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| | RNA, Small Interfering |
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| | Signal Transduction |
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| | Transcriptome |
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| | Transplantation, Heterologous |
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| | Wnt Proteins |
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| K10plus-PPN: | 1580495508 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis / Augustin, Iris [VerfasserIn]; 2012 (Online-Ressource)
