| Online-Ressource |
Verfasst von: | Jobst, Bertram [VerfasserIn]  |
| Weinheimer, Oliver [VerfasserIn]  |
| Trauth, Mila [VerfasserIn]  |
| Becker, Nikolaus [VerfasserIn]  |
| Tremper, Jan [VerfasserIn]  |
| Delorme, Stefan [VerfasserIn]  |
| Eichinger, Monika [VerfasserIn]  |
| Kauczor, Hans-Ulrich [VerfasserIn]  |
| Wielpütz, Mark Oliver [VerfasserIn]  |
Titel: | Effect of smoking cessation on quantitative computed tomography in smokers at risk in a lung cancer screening population |
Verf.angabe: | Bertram J. Jobst, Oliver Weinheimer, Mila Trauth, Nikolaus Becker, Erna Motsch, Marie-Luise Groß, Jan Tremper, Stefan Delorme, Anke Eigentopf, Monika Eichinger, Hans-Ulrich Kauczor, Mark O. Wielpütz |
E-Jahr: | 2018 |
Jahr: | 2018-02-01 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 29.08.2018 |
Titel Quelle: | Enthalten in: European radiology |
Ort Quelle: | Berlin : Springer, 1991 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 28(2018), 2, Seite 807-815 |
ISSN Quelle: | 1432-1084 |
| 1613-3757 |
Abstract: | Objective To longitudinally evaluate effects of smoking cessation on quantitative CT in a lung cancer screening cohort of heavy smokers over 4 years.Methods After 4 years, low-dose chest CT was available for 314 long-term ex-smokers (ES), 404 continuous smokers (CS) and 39 recent quitters (RQ) who quitted smoking within 2 years after baseline CT. CT acquired at baseline and after 3 and 4 years was subjected to well-evaluated densitometry software, computing mean lung density (MLD) and 15th percentile of the lung density histogram (15TH).ResultsAt baseline, active smokers showed significantly higher MLD and 15TH (-822±35 and -936±25 HU, respectively) compared to ES (-831±31 and -947±22 HU, p<0.01-0.001). After 3 years, CS again had significantly higher MLD and 15TH (-801±29 and -896±23 HU) than ES (-808±27 and -906±20 HU, p<0.01-0.001) but also RQ (-813±20 and -909±15 HU, p<0.05-0.001). Quantitative CT parameters did not change significantly after 4 years. Importantly, smoking status independently predicted MLD at baseline and year 3 (p<0.001) in multivariate analysis.ConclusionOn quantitative CT, lung density is higher in active smokers than ex-smokers, and sustainably decreases after smoking cessation, reflecting smoking-induced inflammation. Interpretations of quantitative CT data within clinical trials should consider smoking status. Key Points • Lung density is higher in active smokers than ex-smokers. • Lung density sustainably decreases after smoking cessation. • Impact of smoking cessation on lung density is independent of potentially confounding factors. • Smoke-induced pulmonary inflammation and particle deposition influence lung density on CT. |
DOI: | doi:10.1007/s00330-017-5030-6 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: https://doi.org/10.1007/s00330-017-5030-6 |
| Volltext: http://dx.doi.org/10.1007/s00330-017-5030-6 |
| DOI: https://doi.org/10.1007/s00330-017-5030-6 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Biomarker |
| Chronic-obstructive pulmonary disease |
| Emphysema |
| Quantitative computed tomography |
| Smoking cessation |
K10plus-PPN: | 1580495982 |
Verknüpfungen: | → Zeitschrift |
Effect of smoking cessation on quantitative computed tomography in smokers at risk in a lung cancer screening population / Jobst, Bertram [VerfasserIn]; 2018-02-01 (Online-Ressource)