Molecular subgroups of medulloblastoma

• Verfasst von: Northcott, Paul A. [VerfasserIn]
• Verfasst von: Pfister, Stefan [VerfasserIn]
• Titel: Molecular subgroups of medulloblastoma
• Verf.angabe: Paul A. Northcott, Adrian M. Dubuc, Stefan Pfister, Michael D. Taylor
• Jahr des Originals: 2012
• Umfang: 14 S.
• Fussnoten: Published online: 09 Jan 2014 ; Gesehen am 29.08.2018
• Titel Quelle: Enthalten in: Expert review of neurotherapeutics
• Jahr Quelle: 2014
• Band/Heft Quelle: 12(2012), 7, S. 871-884
• ISSN Quelle: 1744-8360
• DOI: doi:10.1586/ern.12.66
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580496180

Abstract

Recent efforts at stratifying medulloblastomas based on their molecular features have revolutionized our understanding of this morbidity. Collective efforts by multiple independent groups have subdivided medulloblastoma from a single disease into four distinct molecular subgroups characterized by disparate transcriptional signatures, mutational spectra, copy number profiles and, most importantly, clinical features. We present a summary of recent studies that have contributed to our understanding of the core medulloblastoma subgroups, focusing largely on clinically relevant discoveries that have already, and will continue to, shape research.