Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking

• Verfasst von: Mutschler, Jochen [VerfasserIn]
• Verfasst von: Goltz, Christoph von der [VerfasserIn]
• Verfasst von: Dinter, Christina [VerfasserIn]
• Verfasst von: Kiefer, Falk [VerfasserIn]
• Titel: Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking
• Verf.angabe: Jochen Mutschler, Elvira Abbruzzese, Christoph von der Goltz, Christina Dinter, Arian Mobascher, Holger Thiele, Amalia Diaz-Lacava, Norbert Dahmen, Jürgen Gallinat, Tomislav Majic, Nadine Petrovsky, Johannes Kornhuber, Norbert Thuerauf, Gerhard Gründer, Jürgen Brinkmeyer, Thomas Wienker, Michael Wagner, Georg Winterer, Falk Kiefer
• E-Jahr: 2012
• Jahr: May 15, 2012
• Umfang: 7 S.
• Fussnoten: Gesehen am 30.08.2018
• Titel Quelle: Enthalten in: European addiction research
• Ort Quelle: Basel : Karger, 1995
• Jahr Quelle: 2012
• Band/Heft Quelle: 18(2012), 5, Seite 246-252
• ISSN Quelle: 1421-9891
• DOI: doi:10.1159/000338276
• Schlagwörter: (s)Neuropeptid Y / (s)Polymorphismus / (s)Nicotin / (s)Tabak / (s)Rauchen / (s)Genetik
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Online-Ausgabe: Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking. - Basel : Karger, 2012. - Online-Ressource
• K10plus-PPN: 1580529240

Abstract

<b><i>Background:</i></b> Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking. <b><i>Methods:</i></b> In a population-based case-control multicenter study designed for tobacco addiction research, a total of 550 Caucasian current smokers, and 544 never-smokers were genotyped for SNP rs16147 and behaviorally characterized with the State-Trait Anxiety Inventory (STAI). <b><i>Results:</i></b> Subjects with TT genotype of the SNP rs16147 were significantly more frequently smokers than never-smokers (p = 0.046). In addition, TT genotype exhibited increased state anxiety scores compared to carriers of the C allele (p = 0.037). <b><i>Conclusions:</i></b> Our results provide evidence for an involvement of the functionally relevant SNP rs16147 in the pathophysiology of tobacco dependence. Further studies are needed to confirm our findings.