Interleukin-1R signaling is essential for induction of proapoptotic cd8 t cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice

• Verfasst von: Jöckel, Lars Thomas [VerfasserIn]
• Verfasst von: Wallich, Reinhard [VerfasserIn]
• Titel: Interleukin-1R signaling is essential for induction of proapoptotic cd8 t cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice
• Verf.angabe: Lars T. Joeckel, Reinhard Wallich, Sunil S. Metkar, Christopher J. Froelich, Markus M. Simon, and Christoph Borner
• E-Jahr: 2012
• Jahr: 6 June 2012
• Umfang: 7 S.
• Fussnoten: Published ahead of print 6 June 2012 ; Gesehen am 30.08.2018
• Titel Quelle: Enthalten in: Journal of virology
• Ort Quelle: Baltimore, Md. : Soc., 1967
• Jahr Quelle: 2012
• Band/Heft Quelle: 86(2012), 16, Seite 8713-8719
• ISSN Quelle: 1098-5514
• DOI: doi:10.1128/JVI.00682-12
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580533183

Abstract

The T cell granule exocytosis pathway is essential to control hepatotropic lymphocytic choriomeningitis virus strain WE (LCMV-WE) but also contributes to the observed pathology in mice. Although effective antiviral T cell immunity and development of viral hepatitis are strictly dependent on perforin and granzymes, the molecular basis underlying induction of functionally competent virus-immune T cells, including participation of the innate immune system, is far from being resolved. We demonstrate here that LCMV-immune T cells of interleukin-1 receptor (IL-1R)-deficient mice readily express transcripts for perforin and granzymes but only translate perforin, resulting in the lack of proapoptotic potential in vitro. LCMV is not cleared in IL-1R-deficient mice, and yet the infected mice develop neither splenomegaly nor hepatitis. These results demonstrate that IL-1R signaling is central to the induction of proapoptotic CD8 T cell immunity, including viral clearance and associated tissue injuries in LCMV infection.