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Verfasst von:Aykut, Güçlü [VerfasserIn]   i
Titel:Correction of dilutional anemia induces renal dysfunction in diabetic patients undergoing coronary artery bypass grafting
Titelzusatz:a consequence of microcirculatory alterations?
Verf.angabe:Güçlü Aykut, Meltem Kilercik, Cem Arıtürk, Halim Ulugöl, Uğur Aksu, Türkan Kudsioğlu, Nazan Atalan, Nihan Yapıcı, Hasan Karabulut, Fevzi Toraman
Jahr:2018
Jahr des Originals:2017
Umfang:6 S.
Fussnoten:First online: 22 March 2017 ; Gesehen am 04.09.2018
Titel Quelle:Enthalten in: Journal of nephrology
Ort Quelle:Milano : Springer, 1996
Jahr Quelle:2018
Band/Heft Quelle:31(2018), 3, Seite 417-422
ISSN Quelle:1724-6059
Abstract:BACKGROUND: In this study we aimed to evaluate the effects of dilutional anemia resulting from cardiopulmonary bypass (CPB) and its correction with red blood cell (RBC) transfusion on tissue oxygenation and renal function in diabetic patients undergoing coronary artery bypass grafting (CABG). METHOD: 70 diabetic patients who underwent elective CABG and whose hematocrit values had been between 24-28% at any time during CBP were prospectively randomized and equally allocated to two groups: patients who received RBC during CPB (group I, n = 35) vs. did not receive RBC during CPB (group II, n = 35). Besides routine hemodynamic and biochemical parameters, biomarkers of ischemia and renal injury such as ischemia modified albumin (IMA), protein oxidation parameters [advanced oxidative protein products (AOPP), total thiol (T-SH)], neutrophil gelatinase-associated lipocalin (NGAL) and estimated glomerular filtration rate (eGFR) were measured in both groups. RESULTS: In group I, T-SH, NGAL and urea levels were found to be significantly increased postoperatively compared to preoperative measurements (p < 0.05). Also, postoperatively, NGAL, creatinine, aspartate aminotransferase and AOPP levels were higher in group I than group II (p < 0.05). CONCLUSION: The correction of anemia with RBC transfusion in diabetic patients undergoing CABG could increase the risk of renal injury. Further studies verifying the effects of blood transfusions at the microcirculatory level are needed to optimize the efficacy of transfusions.
DOI:doi:10.1007/s40620-017-0388-8
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s40620-017-0388-8
 DOI: https://doi.org/10.1007/s40620-017-0388-8
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Acute kidney dysfunction
 Cardiac surgery
 Diabetes
 Microcirculation
 Transfusion
K10plus-PPN:1580649807
Verknüpfungen:→ Zeitschrift

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