| |  Online-Ressource |
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| Verfasst von: | Horn, Sebastian [VerfasserIn]  |
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| | Schilling, Ramon [VerfasserIn] |
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| | Sticht, Carsten [VerfasserIn] |
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| | Ploesser, Michaela [VerfasserIn] |
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| | Sprick, Martin [VerfasserIn] |
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| | Leverkus, Martin [VerfasserIn] |
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| Titel: | Caspase-10 negatively regulates Caspase-8-Mediated cell death, switching the response to CD95L in favor of NF-[kappa]B activation and cell survival |
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| Verf.angabe: | Sebastian Horn, Michelle A. Hughes, Ramon Schilling, Carsten Sticht, Tencho Tenev, Michaela Ploesser, Pascal Meier, Martin R. Sprick, Marion MacFarlane, and Martin Leverkus |
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| E-Jahr: | 2017 |
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| Jahr: | April 25, 2017 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 04.09.2018 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 19(2017), 4, Seite 785-797 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Summary: Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD. By elucidating the function of the caspase-8 homolog, caspase-10, we discover that caspase-10 negatively regulates caspase-8-mediated cell death. Significantly, we reveal that caspase-10 reduces DISC association and activation of caspase-8. Furthermore, we extend our co-operative/hierarchical binding model of caspase-8/cFLIP and show that caspase-10 does not compete with caspase-8 for binding to FADD. Utilizing caspase-8-knockout cells, we demonstrate that caspase-8 is required upstream of both cFLIP and caspase-10 and that DISC formation critically depends on the scaffold function of caspase-8. We establish that caspase-10 rewires DISC signaling to NF-κB activation/cell survival and demonstrate that the catalytic activity of caspase-10, and caspase-8, is redundant in gene induction. Thus, our data are consistent with a model in which both caspase-10 and cFLIP coordinately regulate CD95L-mediated signaling for death or survival. |
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| DOI: | doi:10.1016/j.celrep.2017.04.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1016/j.celrep.2017.04.010 |
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| | kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S2211124717304850 |
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| | DOI: https://doi.org/10.1016/j.celrep.2017.04.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | caspase-10 |
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| | caspase-8 |
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| | CD95 |
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| | cell death |
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| | cFLIP |
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| | DISC |
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| | NF-κB |
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| K10plus-PPN: | 1580670792 |
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| Verknüpfungen: | → Zeitschrift |
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Caspase-10 negatively regulates Caspase-8-Mediated cell death, switching the response to CD95L in favor of NF-[kappa]B activation and cell survival / Horn, Sebastian [VerfasserIn]; April 25, 2017 (Online-Ressource)
