High-density peptide arrays for Malaria vaccine development

• Verfasst von: Löffler, Felix [VerfasserIn]
• Verfasst von: Pfeil, Johannes [VerfasserIn]
• Verfasst von: Heiß, Kirsten [VerfasserIn]
• Titel: High-density peptide arrays for Malaria vaccine development
• Verf.angabe: Felix F. Loeffler, Johannes Pfeil, Kirsten Heiss
• Umfang: 14 S.
• Fussnoten: Gesehen am 04.09.2018
• Titel Quelle: Enthalten in: Vaccine design
• Jahr Quelle: 2016
• Band/Heft Quelle: (2016), S. 569-582
• ISBN Quelle: 978-1-4939-3387-7
• DOI: doi:10.1007/978-1-4939-3387-7_32
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580673716

Abstract

The development of an efficacious and practicable vaccine conferring sterile immunity towards a Plasmodium infection represents a not yet achieved goal. A crucial factor for the impact of a given anti-plasmodial subunit vaccine is the identification of the most potent parasitic components required to induce protection from both infection and disease. Here, we present a method based on a novel high-density peptide array technology that allows for a flexible readout of malaria antibodies. Peptide arrays applied as a screening method can be used to identify novel immunogenic antibody epitopes under a large number of potential antigens/peptides. Ultimately, discovered antigen candidates and/or epitope sequences can be translated into vaccine prototype design. The technology can be further utilized to unravel antibody-mediated immune responses (e.g., involved in the establishment of semi-immunity) and moreover to confirm vaccine potency during the process of clinical development by verifying the induced antibody responses following vaccination.