| |  Online-Ressource |
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| Verfasst von: | Veinalde, Rūta [VerfasserIn]  |
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| | Großardt, Christian [VerfasserIn] |
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| | Hartmann, Laura [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Kalle, Christof von [VerfasserIn] |
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| | Ungerechts, Guy [VerfasserIn] |
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| | Engeland, Christine Elisabeth [VerfasserIn] |
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| Titel: | Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation |
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| Verf.angabe: | Rūta Veinalde, Christian Grossardt, Laura Hartmann, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts, and Christine E. Engeland |
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| E-Jahr: | 2017 |
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| Jahr: | 2017 Jan 31 |
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| Umfang: | 11 S. |
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| Teil: | volume:6 |
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| | year:2017 |
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| | number:4 |
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| | extent:11 |
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| Fussnoten: | Gesehen am 05.09.2018 |
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| Titel Quelle: | Enthalten in: OncoImmunology |
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| Ort Quelle: | Abingdon : Taylor & Franics, 2012 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 6(2017,4) Artikel-Nummer e1285992, 11 Seiten |
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| ISSN Quelle: | 2162-402X |
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| Abstract: | Combination of oncolytic virotherapy with immunomodulators is emerging as a promising therapeutic strategy for numerous tumor entities. In this study, we developed measles Schwarz vaccine strain vectors encoding immunomodulators to support different phases in the establishment of antitumor immune responses. Therapeutic efficacy of the novel vectors was evaluated in the immunocompetent MC38cea tumor model. We identified vectors encoding an IL-12 fusion protein (MeVac FmIL-12) and an antibody against PD-L1 (MeVac anti-PD-L1), respectively, as the most effective. Treatment of established tumors with MeVac FmIL-12 achieved 90% complete remissions. Profiling of the tumor immune microenvironment revealed activation of a type 1 T helper cell-directed response, with MeVac FmIL-12 ensuring potent early natural killer and effector T cell activation as well as upregulation of the effector cytokines IFN-γ and TNF-α. CD8+ T cells were found to be essential for the therapeutic efficacy of MeVac FmIL-12. Results of this study present MeVac FmIL-12 as a novel approach for targeted IL-12 delivery and elucidate mechanisms of successful immunovirotherapy. |
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| DOI: | doi:10.1080/2162402X.2017.1285992 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1080/2162402X.2017.1285992 |
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| | Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414860/ |
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| | DOI: https://doi.org/10.1080/2162402X.2017.1285992 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1580706851 |
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| Verknüpfungen: | → Zeitschrift |
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Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation / Veinalde, Rūta [VerfasserIn]; 2017 Jan 31 (Online-Ressource)
