Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles

• Verfasst von: Nold, Philipp [VerfasserIn]
• Verfasst von: Jungebluth, Philipp [VerfasserIn]
• Titel: Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles
• Titelzusatz: a prerequisite for in vivo tracking of MSCs
• Verf.angabe: Philipp Nold, Raimo Hartmann, Neus Feliu, Karsten Kantner, Mahmoud Gamal, Beatriz Pelaz, Jonas Hühn, Xing Sun, Philipp Jungebluth, Pablo del Pino, Holger Hackstein, Paolo Macchiarini, Wolfgang J. Parak and Cornelia Brendel
• E-Jahr: 2017
• Jahr: 29 March 2017
• Umfang: 11 S.
• Fussnoten: Gesehen am 04.12.2019
• Titel Quelle: Enthalten in: Journal of nanobiotechnology
• Ort Quelle: London : Biomed Central, 2003
• Jahr Quelle: 2017
• Band/Heft Quelle: 15(2017,1) Artikel-Nummer 24, 11 Seiten
• ISSN Quelle: 1477-3155
• DOI: doi:10.1186/s12951-017-0258-5
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Errata: Nold, Philipp: Correction to
• K10plus-PPN: 1580711537

Abstract

Mesenchymal stromal cells (MSCs) have an inherent migratory capacity towards tumor tissue in vivo. With the future objective to quantify the tumor homing efficacy of MSCs, as first step in this direction we investigated the use of inorganic nanoparticles (NPs), in particular ca. 4 nm-sized Au NPs, for MSC labeling. Time dependent uptake efficiencies of NPs at different exposure concentrations and times were determined via inductively coupled plasma mass spectrometry (ICP-MS).