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| Verfasst von: | Ball, Claudia R. [VerfasserIn]  |
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| | Oppel, Felix [VerfasserIn] |
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| | Ehrenberg, Karl Roland [VerfasserIn] |
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| | Dubash, Taronish Dorab [VerfasserIn] |
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| | Dieter, Sebastian M. [VerfasserIn] |
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| | Hoffmann, Christopher M. [VerfasserIn] |
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| | Abel, Ulrich [VerfasserIn] |
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| | Herbst, Friederike [VerfasserIn] |
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| | Koch, Moritz [VerfasserIn] |
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| | Werner, Jens [VerfasserIn] |
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| | Bergmann, Frank [VerfasserIn] |
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| | Schmidt, Manfred [VerfasserIn] |
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| | Kalle, Christof von [VerfasserIn] |
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| | Scholl, Claudia [VerfasserIn] |
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| | Fröhling, Stefan [VerfasserIn] |
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| | Brors, Benedikt [VerfasserIn] |
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| | Weichert, Wilko [VerfasserIn] |
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| | Weitz, Jürgen [VerfasserIn] |
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| | Glimm, Hanno [VerfasserIn] |
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| Titel: | Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts |
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| Verf.angabe: | Claudia R Ball, Felix Oppel, Karl Roland Ehrenberg, Taronish D Dubash, Sebastian M Dieter, Christopher M Hoffmann, Ulrich Abel, Friederike Herbst, Moritz Koch, Jens Werner, Frank Bergmann, Naveed Ishaque, Manfred Schmidt, Christof von Kalle, Claudia Scholl, Stefan Fröhling, Benedikt Brors, Wilko Weichert, Jürgen Weitz and Hanno Glimm |
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| E-Jahr: | 2017 |
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| Jahr: | 19 May 2017 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 06.09.2018 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2009 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 9(2017), 7, Seite 918-932 |
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| ISSN Quelle: | 1757-4684 |
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| Abstract: | Although tumor‐initiating cell (TIC) self‐renewal has been postulated to be essential in progression and metastasis formation of human pancreatic adenocarcinoma (PDAC), clonal dynamics of TICs within PDAC tumors are yet unknown. Here, we show that long‐term progression of PDAC in serial xenotransplantation is driven by a succession of transiently active TICs producing tumor cells in temporally restricted bursts. Clonal tracking of individual, genetically marked TICs revealed that individual tumors are generated by distinct sets of TICs with very little overlap between subsequent xenograft generations. An unexpected functional and phenotypic plasticity of pancreatic TICs in vivo underlies the recruitment of inactive TIC clones in serial xenografts. The observed clonal succession of TIC activity in serial xenotransplantation is in stark contrast to the continuous activity of limited numbers of self‐renewing TICs within a fixed cellular hierarchy observed in other epithelial cancers and emphasizes the need to target TIC activation, rather than a fixed TIC population, in PDAC. |
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| DOI: | doi:10.15252/emmm.201607354 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.15252/emmm.201607354 |
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| | kostenfrei: Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494525/ |
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| | DOI: https://doi.org/10.15252/emmm.201607354 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1580747914 |
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| Verknüpfungen: | → Zeitschrift |
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Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts / Ball, Claudia R. [VerfasserIn]; 19 May 2017 (Online-Ressource)
