Usefulness of Heart Rate to Predict One-Year Mortality in Patients With Atrial Fibrillation and Acute Myocardial Infarction (from the OMEGA Trial)

• Verfasst von: Li, Jin [VerfasserIn]
• Verfasst von: Becker, Rüdiger [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Titel: Usefulness of Heart Rate to Predict One-Year Mortality in Patients With Atrial Fibrillation and Acute Myocardial Infarction (from the OMEGA Trial)
• Verf.angabe: Jin Li, Ruediger Becker, Bernhard Rauch, Rudolf Schiele, Steffen Schneider, Thomas Riemer, Frank Diller, Helmut Gohlke, Martin Gottwik, Gerhard Steinbeck, Georg Sabin, Hugo A. Katus, Jochen Senges (OMEGA Study Group)
• Jahr: 2013
• Jahr des Originals: 2012
• Umfang: 5 S.
• Fussnoten: Available online 29 December 2012 ; Gesehen am 06.09.2018
• Titel Quelle: Enthalten in: The American journal of cardiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1958
• Jahr Quelle: 2013
• Band/Heft Quelle: 111(2013), 6, Seite 811-815
• ISSN Quelle: 1879-1913
• DOI: doi:10.1016/j.amjcard.2012.11.048
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580750362

Abstract

In the setting of acute myocardial infarction and sinus rhythm, the heart rate (HR) has been demonstrated to correlate closely with mortality. In patients presenting with acute myocardial infarction and atrial fibrillation (AF) on admission, however, the prognostic relevance of the HR has not yet been systematically addressed. A post hoc subgroup analysis of the data from the OMEGA trial was conducted to analyze whether the admission HR determines the 1-year mortality in patients presenting with AF in the setting of acute myocardial infarction. Of 3,851 patients enrolled in the OMEGA study, 211 (6%) presented with AF on admission. This subgroup was dichotomized according to the admission HR (cutoff 95 beats/min). Multiple regression analysis revealed that an admission HR of ≥95 beats/min independently determined the 1-year mortality in patients with AF (odds ratio 4.69, 95% confidence interval 1.47 to 15.01; p = 0.01). In conclusion, this is the first study demonstrating that a high HR (≥95 beats/min) on admission in patients with AF and acute myocardial infarction is associated with an almost fivefold mortality risk.