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Status: Bibliographieeintrag

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Verfasst von:Tsagogiorgas, Charalambos [VerfasserIn]   i
 Wedel, Johannes [VerfasserIn]   i
 Hottenrott, Maximilia C. [VerfasserIn]   i
 Schneider, Michael Oliver [VerfasserIn]   i
 Binzen, Uta [VerfasserIn]   i
 Greffrath, Wolfgang [VerfasserIn]   i
 Treede, Rolf-Detlef [VerfasserIn]   i
 Waldherr, Rüdiger [VerfasserIn]   i
 Krämer, Bernhard [VerfasserIn]   i
 Thiel, Manfred [VerfasserIn]   i
 Schnülle, Peter [VerfasserIn]   i
 Yard, Benito A. [VerfasserIn]   i
 Höger, Simone [VerfasserIn]   i
Titel:N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates is chemia-induced acute kidney injury in rat
Verf.angabe:Charalambos Tsagogiorgas, Johannes Wedel, Maximilia Hottenrott, Michael O. Schneider, Uta Binzen, Wolfgang Greffrath, Rolf-Detlef Treede, Bastian Theisinger, Sonja Theisinger, Rüdiger Waldherr, Bernhard K. Krämer, Manfred Thiel, Peter Schnuelle, Benito A. Yard, Simone Hoeger
E-Jahr:2012
Jahr:August 20, 2012
Umfang:12 S.
Fussnoten:Gesehen am 10.09.2018
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2012
Band/Heft Quelle:7(2012,8) Artikel-Nummer e43525, 12 Seiten
ISSN Quelle:1932-6203
Abstract:Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N-octanoyl-dopamine (NOD) activates TRPV1 and if it improves AKI. These properties of NOD and its intrinsic anti-inflammatory character were compared with those of dopamine (DA). TRPV1 activation and anti-inflammatory properties of NOD and DA were tested using primary cell cultures in vitro. The influence of NOD and DA on AKI was tested in a prospective, randomized, controlled animal study with 42 inbred male Lewis rats (LEW, RT1), treated intravenously with equimolar concentrations of DA or NOD one hour before the onset of warm ischemia and immediately before clamp release. NOD, but not DA, activates TRPV1 channels in isolated dorsal root ganglion neurons (DRG) that innervate several tissues including kidney. In TNFα stimulated proximal tubular epithelial cells, inhibition of NFκB and subsequent inhibition of VCAM1 expression by NOD was significantly stronger than by DA. NOD improved renal function compared to DA and saline controls. Histology revealed protective effects of NOD on tubular epithelium at day 5 and a reduced number of monocytes in renal tissue of DA and NOD treated rats. Our data demonstrate that NOD but not DA activates TRPV1 and that NOD has superior anti-inflammatory properties in vitro. Although NOD mitigates deterioration in renal function after AKI, further studies are required to assess to what extend this is causally related to TRPV1 activation and/or desensitization.
DOI:doi:10.1371/journal.pone.0043525
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1371/journal.pone.0043525
 kostenfrei: Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043525
 DOI: https://doi.org/10.1371/journal.pone.0043525
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Dopamine
 Epithelial cells
 Inflammation
 Ischemia
 Kidneys
 Neurons
 Renal ischemia
 Renal system
K10plus-PPN:1580822223
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