| |  Online-Ressource |
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| Verfasst von: | Bliss, Carly M. [VerfasserIn]  |
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| | Viebig, Nicola [VerfasserIn] |
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| | Leroy, Odile [VerfasserIn] |
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| Titel: | Viral vector malaria vaccines induce high-level T cell and antibody responses in West African children and infants |
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| Verf.angabe: | Carly M. Bliss, Abdoulie Drammeh, Georgina Bowyer, Guillaume S. Sanou, Ya Jankey Jagne, Oumarou Ouedraogo, Nick J. Edwards, Casimir Tarama, Nicolas Ouedraogo, Mireille Ouedraogo, Jainaba Njie-Jobe, Amidou Diarra, Muhammed O. Afolabi, Alfred B. Tiono, Jean Baptiste Yaro, Uche J. Adetifa, Susanne H. Hodgson, Nicholas A. Anagnostou, Rachel Roberts, Christopher J. A. Duncan, Riccardo Cortese, Nicola K. Viebig, Odile Leroy, Alison M. Lawrie, Katie L. Flanagan, Beate Kampmann, Egeruan B. Imoukhuede, Sodiomon B. Sirima, Kalifa Bojang, Adrian V. S. Hill, Issa Nébié, and Katie J. Ewer |
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| E-Jahr: | 2017 |
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| Jahr: | 22 February 2017 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 11.09.2018 |
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| Titel Quelle: | Enthalten in: Molecular therapy |
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| Ort Quelle: | Amsterdam : Elsevier, 2000 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 25(2017), 2, Seite 547-559 |
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| ISSN Quelle: | 1525-0024 |
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| Abstract: | Heterologous prime-boosting with viral vectors encoding the pre-erythrocytic antigen thrombospondin-related adhesion protein fused to a multiple epitope string (ME-TRAP) induces CD8+ T cell-mediated immunity to malaria sporozoite challenge in European malaria-naive and Kenyan semi-immune adults. This approach has yet to be evaluated in children and infants. We assessed this vaccine strategy among 138 Gambian and Burkinabe children in four cohorts: 2- to 6-year olds in The Gambia, 5- to 17-month-olds in Burkina Faso, and 5- to 12-month-olds and 10-week-olds in The Gambia. We assessed induction of cellular immunity, taking into account the distinctive hematological status of young infants, and characterized the antibody response to vaccination. T cell responses peaked 7 days after boosting with modified vaccinia virus Ankara (MVA), with highest responses in infants aged 10 weeks at priming. Incorporating lymphocyte count into the calculation of T cell responses facilitated a more physiologically relevant comparison of cellular immunity across different age groups. Both CD8+ and CD4+ T cells secreted cytokines. Induced antibodies were up to 20-fold higher in all groups compared with Gambian and United Kingdom (UK) adults, with comparable or higher avidity. This immunization regimen elicited strong immune responses, particularly in young infants, supporting future evaluation of efficacy in this key target age group for a malaria vaccine. |
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| DOI: | doi:10.1016/j.ymthe.2016.11.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1016/j.ymthe.2016.11.003 |
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| | kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S1525001616453864 |
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| | DOI: https://doi.org/10.1016/j.ymthe.2016.11.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antibodies |
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| | malaria |
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| | Phase I trial |
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| | T cells |
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| | vaccine |
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| | viral vectors |
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| K10plus-PPN: | 1580849865 |
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| Verknüpfungen: | → Zeitschrift |
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Viral vector malaria vaccines induce high-level T cell and antibody responses in West African children and infants / Bliss, Carly M. [VerfasserIn]; 22 February 2017 (Online-Ressource)
