Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations

• Verfasst von: Costello, Joseph [VerfasserIn]
• Verfasst von: Islinger, Markus [VerfasserIn]
• Titel: Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations
• Verf.angabe: Joseph L. Costello, Inês G. Castro, Tina A. Schrader, Markus Islinger and Michael Schrader
• E-Jahr: 2017
• Jahr: 05 May 2017
• Umfang: 7 S.
• Fussnoten: Gesehen am 11.09.2018
• Titel Quelle: Enthalten in: Cell cycle
• Ort Quelle: Abingdon : Taylor & Francis Group, 2002
• Jahr Quelle: 2017
• Band/Heft Quelle: 16(2017), 11, Seite 1039-1045
• ISSN Quelle: 1551-4005
• DOI: doi:10.1080/15384101.2017.1314422
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ACBD4
• Sach-SW: ER
• Sach-SW: membrane contact sites
• Sach-SW: Peroxisomes
• Sach-SW: VAPB
• K10plus-PPN: 1580857140

Abstract

Cooperation between cellular organelles such as mitochondria, peroxisomes and the ER is essential for a variety of important and diverse metabolic processes. Effective communication and metabolite exchange requires physical linkages between the organelles, predominantly in the form of organelle contact sites. At such contact sites organelle membranes are brought into close proximity by the action of molecular tethers, which often consist of specific protein pairs anchored in the membrane of the opposing organelles. Currently numerous tethering components have been identified which link the ER with multiple other organelles but knowledge of the factors linking the ER with peroxisomes is limited. Peroxisome-ER interplay is important because it is required for the biosynthesis of unsaturated fatty acids, ether-phospholipids and sterols with defects in these functions leading to severe diseases. Here, we characterize acyl-CoA binding domain protein 4 (ACBD4) as a tail-anchored peroxisomal membrane protein which interacts with the ER protein, vesicle-associated membrane protein-associated protein-B (VAPB) to promote peroxisome-ER associations.