Association of serum soluble urokinase receptor levels with progression of kidney disease in children

• Verfasst von: Schaefer, Franz [VerfasserIn]
• Verfasst von: Trachtman, Howard [VerfasserIn]
• Verfasst von: Wühl, Elke [VerfasserIn]
• Verfasst von: Kirchner, Marietta [VerfasserIn]
• Titel: Association of serum soluble urokinase receptor levels with progression of kidney disease in children
• Verf.angabe: Franz Schaefer, Howard Trachtman, Elke Wühl, Marietta Kirchner, Salim S. Hayek, Ali Anarat, Ali Duzova, Sevgi Mir, Dusan Paripovic, Alev Yilmaz, Francesca Lugani, Klaus Arbeiter, Mieczyslaw Litwin, Jun Oh, Maria Chiara Matteucci, Jutta Gellermann, Simone Wygoda, Augustina Jankauskiene, Günter Klaus, Jiri Dusek, Sara Testa, Aleksandra Zurowska, Alberto Caldas Afonso, Melissa Tracy, Changli Wei, Sanja Sever, William Smoyer, Jochen Reiser
• E-Jahr: 2017
• Jahr: September 5, 2017
• Umfang: ?
• Fussnoten: Published Online: September 5, 2017 ; Gesehen am 12.09.2018
• Titel Quelle: Enthalten in: JAMA pediatrics
• Ort Quelle: Chicago, Ill. : American Medical Association, 2013
• Jahr Quelle: 2017
• Band/Heft Quelle: 171(2017,11) Artikel-Nummer e172914
• ISSN Quelle: 2168-6211
• DOI: doi:10.1001/jamapediatrics.2017.2914
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580901972

Abstract

Importance: Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level and cystatin C–derived estimated glomerular filtration rate (eGFR) and assessment of proteinuria in spot or timed urine samples, are of limited value in identifying patients at risk of progressive kidney function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 in adults. Objective; To determine whether elevated suPAR levels are associated with renal disease progression in children with CKD. Conclusions and Relevance: Patients with high suPAR levels were more likely to have progression of their kidney disease. Further studies should determine whether suPAR levels can identify children at risk for future CKD.