The seven faces of SIRT7

• Verfasst von: Blank, Maximilian Felix [VerfasserIn]
• Verfasst von: Grummt, Ingrid [VerfasserIn]
• Titel: The seven faces of SIRT7
• Verf.angabe: Maximilian F. Blank and Ingrid Grummt
• E-Jahr: 2017
• Jahr: 2017 Jan 9
• Umfang: 8 S.
• Fussnoten: Gesehen am 13.09.2018
• Titel Quelle: Enthalten in: Transcription
• Ort Quelle: Austin, Tex. : Landes Bioscience, 2010
• Jahr Quelle: 2017
• Band/Heft Quelle: 8(2017), 2, Seite 67-74
• ISSN Quelle: 2154-1272
• DOI: doi:10.1080/21541264.2016.1276658
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580931456

Abstract

SIRT7, a member of the sirtuin family of NAD+-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functions of SIRT7 are poorly defined. Here, we review recent progress in SIRT7 research and elaborate the main pathways in which SIRT7 participates.