Precision medicine approach to genetic cardiomyopathy

• Verfasst von: Filonenko, Kateryna [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Meder, Benjamin [VerfasserIn]
• Titel: Precision medicine approach to genetic cardiomyopathy
• Verf.angabe: K. Filonenko, H.A. Katus, B. Meder
• E-Jahr: 2017
• Jahr: 26 June 2017
• Umfang: 8 S.
• Fussnoten: Gesehen am 29.08.2019
• Titel Quelle: Enthalten in: Herz
• Ort Quelle: München : Urban & Vogel, 1997
• Jahr Quelle: 2017
• Band/Heft Quelle: 42(2017), 5, Seite 468-475
• ISSN Quelle: 1615-6692
• DOI: doi:10.1007/s00059-017-4592-z
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: „Clustered regularly interspaced short palindromic repeats“
• Sach-SW: Arrhythmia
• Sach-SW: Arrhythmie
• Sach-SW: Clustered regularly interspaced short palindromic repeats
• Sach-SW: Gene repair
• Sach-SW: Genetic testing
• Sach-SW: Genetische Testung
• Sach-SW: Genome-wide association study
• Sach-SW: Genomweite Assoziationsstudie
• Sach-SW: Genreparatur
• Sach-SW: Mutationen
• Sach-SW: Mutations
• Sach-SW: Plötzlicher Herztod
• Sach-SW: Risikobeurteilung
• Sach-SW: Risk assessment
• Sach-SW: Sudden cardiac death
• K10plus-PPN: 1580990908

Abstract

Precision medicine aims to achieve improved survival by strategies that recognize the genetic and phenotypic individuality of patients and stratify treatment accordingly. Genetic cardiomyopathies represent an ideal disease group to fully embark on this concept: they are in total frequent diseases with a marked morbidity and mortality and there is ample knowledge about their predisposing genetic factors and associated functional mechanisms. The current review highlights the genetic etiology and gives examples of the diverse treatment strategies that are envisaged in the future.