Non-invasive tools for the diagnosis of cutaneous melanoma

• Verfasst von: Müller-Christmann, Christine [VerfasserIn]
• Verfasst von: Hänßle, Holger [VerfasserIn]
• Titel: Non-invasive tools for the diagnosis of cutaneous melanoma
• Verf.angabe: C. Fink and H.A. Haenssle
• Jahr: 2017
• Jahr des Originals: 2016
• Umfang: 11 S.
• Fussnoten: Version of record online: 22 November 2016 ; Gesehen am 14.09.2018
• Titel Quelle: Enthalten in: Skin research & technology
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1995
• Jahr Quelle: 2017
• Band/Heft Quelle: 23(2017), 3, Seite 261-271
• ISSN Quelle: 1600-0846
• DOI: doi:10.1111/srt.12350
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: atypical nevus
• Sach-SW: computer-aided multispectral digital analysis
• Sach-SW: dermoscopy
• Sach-SW: diagnostic devices
• Sach-SW: dysplastic nevus
• Sach-SW: electrical impedance spectroscopy
• Sach-SW: in vivo multiphoton tomography
• Sach-SW: infrared thermal image analysis
• Sach-SW: melanoma
• Sach-SW: Raman spectroscopy
• Sach-SW: reflectance confocal microscopy
• Sach-SW: sequential digital dermoscopy
• Sach-SW: stepwise two-photon-laser spectroscopy
• Sach-SW: total body photography
• K10plus-PPN: 1580997740

Abstract

Background While the excisional biopsy and histological examination of suspicious lesions remains the current gold standard for diagnosing cutaneous melanoma (CM), there is a demand for more objective and non-invasive examination methods that may support clinicians in their decision when to biopsy or not. Methods This review is based on publications and guidelines retrieved by a selective search in PubMed and MEDLINE and focused on non-invasive diagnostic strategies for detecting melanoma. Results Ten different non-invasive techniques were compared with regard to applicability, status of development, and resources necessary for introduction into clinical routine (dermoscopy, sequential digital dermoscopy, total body photography, computer-aided multispectral digital analysis, electrical impedance spectroscopy, Raman spectroscopy, reflectance confocal microscopy, multiphoton tomography, stepwise two-photon-laser spectroscopy, quantitative dynamic infrared imaging). In an effort to create a classification based on our analyses, we suggest to differentiate i) tools for screening of patients in daily clinical routine, ii) tools for examination of a restricted number of preselected lesions that produce an automated diagnostic score, iii) tools for examination of a restricted number of preselected lesions at specialized centers requiring extensive training, iv) devices at an experimental stage of development. Conclusion None of the discussed examination techniques is able to provide a definite and final diagnosis or to completely replace the histopathological examination. Up to date, the need for fully automated devices offering a complete skin cancer screening has not been satisfied.