Pain management in photodynamic therapy using a nitrous oxide/oxygen mixture

• Verfasst von: Müller-Christmann, Christine [VerfasserIn]
• Verfasst von: Uhlmann, Lorenz [VerfasserIn]
• Verfasst von: Enk, Alexander [VerfasserIn]
• Verfasst von: Gholam, Patrick [VerfasserIn]
• Titel: Pain management in photodynamic therapy using a nitrous oxide/oxygen mixture
• Titelzusatz: a prospective, within-patient, controlled clinical trial
• Verf.angabe: C. Fink, L. Uhlmann, A. Enk, P. Gholam
• Jahr: 2017
• Umfang: 5 S.
• Fussnoten: First published: 09 July 2016 ; Gesehen am 22.08.2019
• Titel Quelle: Enthalten in: European Academy of Dermatology and VenereologyJournal of the European Academy of Dermatology and Venereology
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1991
• Jahr Quelle: 2017
• Band/Heft Quelle: 31(2017), 1, Seite 70-74
• ISSN Quelle: 1468-3083
• DOI: doi:10.1111/jdv.13788
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581010885

Abstract

Background Photodynamic therapy is an effective treatment for actinic keratoses. Nevertheless, severe pain during the procedure is a serious adverse effect, which leads to interruption or even termination. Complete pain relief remains a difficult challenge. Objective To evaluate the effect of a nitrous oxide/oxygen mixture on pain intensity during photodynamic therapy. Methods This clinical trial has been designed as a prospective, single-centre, explorative, controlled, observational study. Results We were able to detect a significant overall pain reduction of 55.2% after application of a nitrous oxide/oxygen mixture by means of an intra-individual comparison. Furthermore, the total number of therapy interruption significantly decreased by 82% after the inhalation analgesia. Additionally, treatment satisfaction ranged from ‘extremely to very satisfied’. Conclusions This study shows that analgesia by means of a nitrous oxide/oxygen mixture is a very effective and well-tolerated method for achieving significant pain reduction during photodynamic therapy.