Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex

• Verfasst von: Melzer, Sarah [VerfasserIn]
• Verfasst von: Michael, Magdalena [VerfasserIn]
• Verfasst von: Caputi, Antonio [VerfasserIn]
• Verfasst von: Eliava, Marina [VerfasserIn]
• Verfasst von: Fuchs, Elke C. [VerfasserIn]
• Verfasst von: Monyer, Hannah [VerfasserIn]
• Titel: Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex
• Verf.angabe: Sarah Melzer, Magdalena Michael, Antonio Caputi, Marina Eliava, Elke C. Fuchs, Miles A. Whittington, Hannah Monyer
• Jahr: 2012
• Umfang: 5 S.
• Fussnoten: Gesehen am 17.09.2018
• Titel Quelle: Enthalten in: Science
• Ort Quelle: Washington, DC [u.a.] : American Association for the Advancement of Science, 1880
• Jahr Quelle: 2012
• Band/Heft Quelle: 335(2012), 6075, Seite 1506-1510
• ISSN Quelle: 1095-9203
• DOI: doi:10.1126/science.1217139
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581012705

Abstract

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.