| Online-Ressource |
Verfasst von: | Fischer, Katrin [VerfasserIn]  |
| Herzig, Stephan [VerfasserIn]  |
Titel: | Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis |
Verf.angabe: | Katrin Fischer, Henry H Ruiz, Kevin Jhun, Brian Finan, Douglas J Oberlin, Verena van der Heide, Anastasia V Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C. Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C Woods, Stephan Herzig, Dirk Homann, Steffen Jung, Jan Nedergaard, Barbara Cannon, Matthias H Tschöp, Timo D Müller & Christoph Buettner |
E-Jahr: | 2017 |
Jahr: | 17 April 2017 |
Umfang: | 8 S. |
Teil: | volume:23 |
| year:2017 |
| number:5 |
| pages:623-630 |
| extent:8 |
Fussnoten: | Gesehen am 21.08.2019 |
Titel Quelle: | Enthalten in: Nature medicine |
Ort Quelle: | New York, NY : Nature America Inc., 1995 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 23(2017), 5, Seite 623-630 |
ISSN Quelle: | 1546-170X |
Abstract: | Adaptive thermogenesis is the process of heat generation in response to cold stimulation. It is under the control of the sympathetic nervous system, whose chief effector is the catecholamine norepinephrine (NE). NE enhances thermogenesis through β3-adrenergic receptors to activate brown adipose tissue and by 'browning' white adipose tissue. Recent studies have reported that alternative activation of macrophages in response to interleukin (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway, and that this activation provides an alternative source of locally produced catecholamines during the thermogenic process. Here we report that the deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue. Bone marrow-derived macrophages did not release NE in response to stimulation with IL-4, and conditioned media from IL-4-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1), in adipocytes cultured with the conditioned media. Furthermore, chronic treatment with IL-4 failed to increase energy expenditure in wild-type, Ucp1−/− and interleukin-4 receptor-α double-negative (Il4ra−/−) mice. In agreement with these findings, adipose-tissue-resident macrophages did not express TH. Thus, we conclude that alternatively activated macrophages do not synthesize relevant amounts of catecholamines, and hence, are not likely to have a direct role in adipocyte metabolism or adaptive thermogenesis. |
DOI: | doi:10.1038/nm.4316 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1038/nm.4316 |
| Volltext: https://www.nature.com/articles/nm.4316 |
| DOI: https://doi.org/10.1038/nm.4316 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1581079176 |
Verknüpfungen: | → Zeitschrift |
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis / Fischer, Katrin [VerfasserIn]; 17 April 2017 (Online-Ressource)