| |  Online-Ressource |
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| Verfasst von: | Abba, Mohammed L. [VerfasserIn]  |
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| | Patil, Nitin [VerfasserIn] |
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| | Leupold, Jörg [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Allgayer, Heike [VerfasserIn] |
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| Titel: | MicroRNAs as novel targets and tools in cancer therapy |
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| Verf.angabe: | Mohammed L. Abba, Nitin Patil, Jörg H. Leupold, Marcin Moniuszko, Jochen Utikal, Jacek Niklinski, Heike Allgayer |
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| Jahr: | 2017 |
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| Jahr des Originals: | 2016 |
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| Umfang: | 11 S. |
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| Fussnoten: | Available online 1 April 2016 ; Gesehen am 20.09.2018 |
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| Titel Quelle: | Enthalten in: Cancer letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 387(2017), Seite 84-94 |
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| ISSN Quelle: | 1872-7980 |
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| Abstract: | MicroRNAs (miRNAs) are currently experiencing a renewed peak of attention not only as diagnostics but also especially as highly promising novel targets or tools for clinical therapy in several different malignant diseases. Moreover, the recent discovery of competing endogenous RNAs (ceRNAs) as novel miRNA-regulators has contributed exciting insights in this regard. Therefore, this review summarizes and discusses the latest findings on (1) how miRNAs have become therapeutic targets of diverse synthetic antagonists, (2) how novel endogenous regulators of miRNAs such as ceRNAs or pseudogenes could emerge as therapeutics scavenging oncogenic miRNAs and (3) how miRNAs themselves are already, and will increasingly be, used as therapeutics. Recent advances on the importance of miRNA-target affinity and the subcellular localization of miRNAs are also discussed. The potential of these developments in different tumor entities and particular hallmarks of cancer such as metastasis, disease progression, interactions with the tumor microenvironment, or cancer stem cells are equally highlighted. |
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| DOI: | doi:10.1016/j.canlet.2016.03.043 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.canlet.2016.03.043 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S030438351630204X |
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| | DOI: https://doi.org/10.1016/j.canlet.2016.03.043 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer |
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| | Metastasis |
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| | microRNAs |
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| | Stem cells |
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| | Therapy |
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| K10plus-PPN: | 1581137281 |
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| Verknüpfungen: | → Zeitschrift |
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MicroRNAs as novel targets and tools in cancer therapy / Abba, Mohammed L. [VerfasserIn]; 2017 (Online-Ressource)
