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| Verfasst von: | Prato, Vincenzo [VerfasserIn]  |
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| | Taberner, Francisco J. [VerfasserIn] |
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| | Arcourt, Alice [VerfasserIn] |
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| | Tazir, Bassim [VerfasserIn] |
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| | Hammer, Leonie [VerfasserIn] |
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| | Schad, Paulina [VerfasserIn] |
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| | Lechner, Stefan [VerfasserIn] |
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| Titel: | Functional and molecular characterization of mechanoinsensitive “silent” nociceptors |
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| Verf.angabe: | Vincenzo Prato, Francisco J. Taberner, James R.F. Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A. Heppenstall, Ewan S. Smith, and Stefan G. Lechner |
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| E-Jahr: | 2017 |
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| Jahr: | December 12, 2017 |
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| Umfang: | 14 S. |
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| Teil: | volume:21 |
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| | year:2017 |
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| | number:11 |
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| | pages:3102-3115 |
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| | extent:14 |
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| Fussnoten: | Gesehen am 21.09.2018 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 21(2017), 11, Seite 3102-3115 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Summary: Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described. Here, we have identified a subset of peptidergic C-fiber nociceptors that are insensitive to noxious mechanical stimuli under normal conditions but become sensitized to such stimuli when exposed to the inflammatory mediator nerve growth factor (NGF). Strikingly, NGF did not affect mechanosensitivity of other nociceptors. We show that these mechanoinsensitive “silent” nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3) and that the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons. Retrograde tracing revealed that CHRNA3+ nociceptors account for ∼50% of all peptidergic nociceptive afferents innervating visceral organs and deep somatic tissues. Hence, our data suggest that NGF-induced “un-silencing” of CHRNA3+ nociceptors significantly contributes to the development of mechanical hyperalgesia during inflammation. |
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| DOI: | doi:10.1016/j.celrep.2017.11.066 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1016/j.celrep.2017.11.066 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124717317187 |
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| | DOI: https://doi.org/10.1016/j.celrep.2017.11.066 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CHRNA3 |
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| | hyperalgesia |
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| | inflammatory pain |
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| | mechanically insensitive nociceptor |
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| | mechanotransduction |
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| | MIA |
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| | nerve growth factor |
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| | NGF |
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| | Piezo2 |
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| | silent nociceptor |
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| K10plus-PPN: | 1581201397 |
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| Verknüpfungen: | → Zeitschrift |
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Functional and molecular characterization of mechanoinsensitive “silent” nociceptors / Prato, Vincenzo [VerfasserIn]; December 12, 2017 (Online-Ressource)
