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Verfasst von:Abdel-Rahman, Omar M. [VerfasserIn]   i
 Tekbaş, Aysun [VerfasserIn]   i
 Oweira, Hani [VerfasserIn]   i
 Mehrabi, Arianeb [VerfasserIn]   i
Titel:Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma
Titelzusatz:an updated systematic review of 81 epidemiological studies
Verf.angabe:Omar Abdel‐Rahman, Daniel Helbling, Othmar Schöb, Mostafa Eltobgy, Hadeer Mohamed, Jan Schmidt, Anwar Giryes, Arianeb Mehrabi, Satheesh Iype, Hannah John, Aysun Tekbas, Ahmad Zidan, Hani Oweira
Umfang:10 S.
Fussnoten:Gesehen am 24.09.2018
Titel Quelle:Enthalten in: Journal of evidence based medicine
Jahr Quelle:2017
Band/Heft Quelle:10(2017), 4, S. 245-254
ISSN Quelle:1756-5391
Abstract:Background and aims Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and its incidence has increased during the past decade. While hepatitis B and C virus infections and alcohol were established risk factors, the impact of smoking on the incidence and mortality of HCC was needed to be confirmed. Methods We reviewed cohort and case-control studies evaluating the association between cigarette smoking and incidence and mortality of HCC from MEDLINE and Google Scholar. We also checked reference lists of original studies and review articles manually for cross-references up to February 2016. We extracted the relevant information on participant characteristics and study outcomes, as well as information on the methodology of the studies. We also assessed the quality of the included trials using critical appraisal skills program checklists. Meta-analysis was performed by using RevMan 5.3 software. Results A total of 81 studies were included in the systematic review. Pooled OR for HCC development with current smokers was 1.55 (95% CI: 1.46 to 1.65; P < 0.00001). Pooled OR for HCC development with former smokers was 1.39 (95% CI: 1.26 to 1.52; P < 0.00001) and pooled OR for HCC development with heavy smokers was 1.90 (95% CI: 1.68 to 2.14; P < 0.00001). Pooled OR for the mortality of current smokers with HCC was 1.29 (95% CI: 1.23 to 1.34; P < 0.00001); and for former smokers with HCC, it was 1.20 (95% CI: 1.00 to 1.42; P = 0.04). Conclusions Cigarette smoking increases the incidence and mortality of HCC. Further studies are needed to evaluate possible impact of quitting smoking on decreasing this risk.
DOI:doi:10.1111/jebm.12270
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1111/jebm.12270
 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1111/jebm.12270
 DOI: https://doi.org/10.1111/jebm.12270
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:158122141X
Verknüpfungen:→ Zeitschrift

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