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Verfasst von:Jakob, Jens [VerfasserIn]   i
 Rège, Inez von [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Hohenberger, Peter [VerfasserIn]   i
Titel:Impact of hyperthermic isolated limb perfusion on tumour oxygenation in soft tissue sarcoma
Verf.angabe:Jens Jakob, Inez von Rege, Christel Weiss, Peter Hohenberger
E-Jahr:2012
Jahr:04 Sep 2012
Umfang:6 S.
Fussnoten:Published online: 04 Sep 2012 ; Gesehen am 24.09.2018
Titel Quelle:Enthalten in: International journal of hyperthermia and thermal therapies
Ort Quelle:London : Informa UK Limited, 2017
Jahr Quelle:2012
Band/Heft Quelle:28(2012), 7, Seite 591-596
ISSN Quelle:1464-5157
Abstract:Purpose: Hyperthermic isolated limb perfusion (ILP) with recombinant tumour necrosis factor alpha (TNF) and melphalan contributes to limb-saving treatment in patients with locally advanced extremity soft tissue sarcoma (STS). This study was conducted to evaluate the dynamic changes of tumour oxygenation and temperature during ILP and their effects on treatment response.Patients and methods: Tumour oxygenation (pO2) and tumour temperature were measured by intratumourally placed O2-sensitive catheter electrodes in 34 patients who underwent ILP for locally advanced or recurrent STS. Tumour response to ILP was assessed by the fraction of tumour necrosis in the resection specimen.Results: Mean tumour pO2 prior to application of TNF and melphalan was 36 mm Hg (range: 2-116 mm Hg) and dropped significantly to 13 mm Hg (range: 0-67 mm Hg, p = 0.03) during ILP. Mean tumour tissue temperature increased from 34.4°C (range 32.4-36.4) to 38.5°C (range 34.1-40.4, p = 0.0001). The mean fraction of necrosis in the resection specimen was 65% (range 5-99). Only the tumour tissue temperature at the onset of ILP correlated with the extent of tumour necrosis (p = 0.01).Conclusion: ILP with TNF and melphalan induces severe oxygen deprivation in soft tissue sarcoma. However, changes in tumour oxygenation did not correlate with treatment response.
DOI:doi:10.3109/02656736.2012.705945
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3109/02656736.2012.705945
 Volltext: http://dx.doi.org/10.3109/02656736.2012.705945
 DOI: https://doi.org/10.3109/02656736.2012.705945
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Isolated limb perfusion
 Soft tissue sarcoma
 Tumour necrosis factor
 Tumour oxygenation
 Tumour temperature
K10plus-PPN:1581221932
Verknüpfungen:→ Zeitschrift

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