Floppy but not sloppy

• Verfasst von: Aramburu, Iker Valle [VerfasserIn]
• Verfasst von: Lemke, Edward A. [VerfasserIn]
• Titel: Floppy but not sloppy
• Titelzusatz: interaction mechanism of FG-nucleoporins and nuclear transport receptors
• Verf.angabe: Iker Valle Aramburu, Edward A. Lemke
• Umfang: 8 S.
• Fussnoten: Gesehen am 24.09.2018
• Titel Quelle: Enthalten in: Seminars in cell & developmental biology
• Jahr Quelle: 2017
• Band/Heft Quelle: 68(2017), S. 34-41
• ISSN Quelle: 1096-3634
• DOI: doi:10.1016/j.semcdb.2017.06.026
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581249357

Abstract

The nuclear pore complex (NPC) forms a permeability barrier between the nucleus and the cytoplasm. Molecules that are able to cross this permeability barrier encounter different disordered phenylalanine glycine rich nucleoporins (FG-Nups) that act as a molecular filter and regulate the selective NPC crossing of biomolecules. In this review, we provide a current overview regarding the interaction mechanism between FG-Nups and the carrier molecules that recognize and enable the transport of cargoes through the NPC aiming to understand the general molecular mechanisms that facilitate the nucleocytoplasmic transport.