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Verfasst von:Pfeifle, Viktoria Amanda [VerfasserIn]   i
 Frongia, Giovanni [VerfasserIn]   i
Titel:Regenerative capacity of the enteric nervous system after ileoileal anastomoses in a rat model
Verf.angabe:Viktoria Amanda Pfeifle, Stephanie J. Gros, Giovanni Frongia, Karl-Herbert Schäfer, Stefan Holland-Cunz
Jahr:2017
Jahr des Originals:2016
Umfang:6 S.
Teil:volume:27
 year:2017
 number:02
 pages:200-205
 extent:6
Fussnoten:Publikationsdatum: 27. Juli 2016 (online) ; Gesehen am 24.09.2018
Titel Quelle:Enthalten in: European journal of pediatric surgery
Ort Quelle:Stuttgart : Thieme, 1991
Jahr Quelle:2017
Band/Heft Quelle:27(2017), 02, Seite 200-205
ISSN Quelle:1439-359X
Abstract:<p> <b>Purpose</b> The aim of the study was to investigate the regeneration and migration of neuronal progenitor cells of the enteric nervous system during wound healing after intestinal anastomosis in the rat ileum.</p> <p> <b>Methods</b> Experiments were performed in a rat model of ileoileal anastomosis. Rats were humanely killed on day 2 or day 10 after anastomosis, and the anastomotic region was compared with ileum of healthy rats. Immunofluorescent staining was performed with protein gene product 9.5, nestin, and S100 antibodies. Ganglia of the anastomotic region in both the myenteric and submucosal plexus were counted, and their diameters were measured and compared between groups.</p> <p> <b>Results</b> Analysis of number and diameter of ganglia in both myenteric and submucosal plexus showed individual alterations as a reaction to the surgical manipulation. Significantly less ganglia were found in the submucosal plexus in the operated groups at both day 2 (<i>p</i> < 0.01) and day 10 (<i>p</i> < 0.01) than in the control group. In the myenteric plexus in the operated group, there was a difference in the number of ganglia at day 2, but ganglia count had recovered at day 10 and was not significantly different from the control group. However, the diameter of ganglia in the myenteric plexus still significantly decreasing on day 10 after surgery than in the control group (<i>p</i> = 0.046). Nestin and S100 double-staining showed an increased expression of nestin around the anastomotic wound.</p> <p> <b>Conclusion</b> Our findings suggest a regenerative potential of the enteric nervous system after the surgical ileoileal anastomosis. The myenteric plexus appears to recover faster than the submucosal plexus. This recovery might be driven by nestin-positive neuronal progenitor cells.</p>
DOI:doi:10.1055/s-0036-1586200
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1055/s-0036-1586200
 Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1586200
 DOI: https://doi.org/10.1055/s-0036-1586200
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:158125301X
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