Screening for potential prophylactics targeting sporozoite motility through the skin

• Verfasst von: Douglas, Ross G. [VerfasserIn]
• Verfasst von: Reinig, Miriam [VerfasserIn]
• Verfasst von: Frischknecht, Friedrich [VerfasserIn]
• Titel: Screening for potential prophylactics targeting sporozoite motility through the skin
• Verf.angabe: Ross G. Douglas, Miriam Reinig, Matthew Neale and Friedrich Frischknecht
• Fussnoten: Gesehen am 25.09.2018
• Titel Quelle: Enthalten in: Malaria journal
• Jahr Quelle: 2018
• Band/Heft Quelle: 17(2018) Artikel-Nummer 319, 10 Seiten
• ISSN Quelle: 1475-2875
• DOI: doi:10.1186/s12936-018-2469-0
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581268165
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Anti-malarial compounds have not yet been identified that target the first obligatory step of infection in humans: the migration of Plasmodium sporozoites in the host dermis. This movement is essential to find and invade a blood vessel in order to be passively transported to the liver. Here, an imaging screening pipeline was established to screen for compounds capable of inhibiting extracellular sporozoites.