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Verfasst von:Klok, Erik [VerfasserIn]   i
 Schreiber, Karen [VerfasserIn]   i
 Stach-Jablonski, Ksenija [VerfasserIn]   i
Titel:Oral contraception and menstrual bleeding during treatment of venous thromboembolism
Titelzusatz:expert opinion versus current practice : combined results of a systematic review, expert panel opinion and an international survey
Verf.angabe:F.A. Klok, K. Schreiber, K. Stach, W. Ageno, S. Middeldorp, S. Eichinger, A. Delluc, M. Blondon, C. Ay
E-Jahr:2017
Jahr:20 March 2017
Umfang:7 S.
Fussnoten:Available online 20 March 2017 ; Gesehen am 25.09.2018
Titel Quelle:Enthalten in: Thrombosis research
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1972
Jahr Quelle:2017
Band/Heft Quelle:153(2017), Seite 101-107
ISSN Quelle:1879-2472
Abstract:Introduction: The optimal management of oral contraception and menstrual bleeding during treatment of venous thromboembolism (VTE) is largely unknown. We aimed to elicit expert opinion and compare that to current practice as assessed by a world-wide international web-based survey among physicians. Methods: 10 international thrombosis experts and 10 abnormal uterine bleeding experts independently completed a questionnaire containing three hypothetical patient cases each with four different scenarios, and additional queries covering different severities of VTE, patient circumstances, hormonal contraceptives and both thrombotic and bleeding complications. The consensus percentage was set a priori at ≥70%. The same questionnaire with randomized case scenarios was presented to international physicians via newsletters of the ISTH and national scientific communities. Differences between the expert groups and daily clinical care were assessed. Results: Expert recommendations were divergent and differed in several important points from clinical practice. In contrast to common practice in which contraceptives are discontinued at the moment of a VTE diagnosis, the thrombosis experts agreed to continue oral contraception (OC) during the anticoagulation treatment period. Also, experts reached consensus on treating patients with anticoagulation-associated abnormal uterine bleeding with tranexamic acid, although this is not supported by strong evidence from the literature. No consensus was reached on the optimal anticoagulant drug class. Conclusions: International experts' opinions on handling of contraceptives and management of anticoagulant-associated abnormal uterine bleeding in female VTE patients are divergent and management in clinical practice is heterogeneous. There is a great need of further studies on these topics.
DOI:doi:10.1016/j.thromres.2017.03.013
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.thromres.2017.03.013
 Volltext: http://www.sciencedirect.com/science/article/pii/S0049384817302372
 DOI: https://doi.org/10.1016/j.thromres.2017.03.013
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Anticoagulants
 Contraception
 Haemorrhage
 Therapeutics
 Venous thromboembolism
K10plus-PPN:158128652X
Verknüpfungen:→ Zeitschrift

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