| |  Online-Ressource |
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| Verfasst von: | Bandapalli, Obul Reddy [VerfasserIn]  |
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| | Ehrmann, Franziska [VerfasserIn] |
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| | Ehemann, Volker [VerfasserIn] |
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| | Gaida, Matthias [VerfasserIn] |
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| | Macher-Göppinger, Stephan [VerfasserIn] |
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| | Wente, Moritz N. [VerfasserIn] |
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| | Schirmacher, Peter [VerfasserIn] |
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| | Brand, Karsten [VerfasserIn] |
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| Titel: | Down-regulation of CXCL1 inhibits tumor growth in colorectal liver metastasis |
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| Verf.angabe: | Obul R. Bandapalli, Franziska Ehrmann, Volker Ehemann, Matthias Gaida, Stephan Macher-Goeppinger, Moritz Wente, Peter Schirmacher, Karsten Brand |
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| Jahr: | 2012 |
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| Umfang: | 8 S. |
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| Fussnoten: | Available online 29 November 2011 ; Gesehen am 26.09.2018 |
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| Titel Quelle: | Enthalten in: Cytokine |
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| Ort Quelle: | Oxford [u.a.] : Elsevier, 1989 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 57(2012), 1, Seite 46-53 |
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| ISSN Quelle: | 1096-0023 |
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| Abstract: | As part of ongoing studies to obtain a global picture of invasion related events in colorectal liver metastases, here, we report our findings on gene expression of the pro-angiogenic subgroup of chemokines, the CXCL-ELR+ chemokines. Apart from their pro-angiogenic and chemoattractant function, these chemokines appear to also contribute to tumor cell transformation, growth and invasion. In our nude mouse model of colorectal liver metastases, we found CXCL1,2,3,5 and 8 (IL-8) to be up-regulated in the tumor cells of the invasion front as compared to the tumor cells in the inner parts of the tumor. ShRNA mediated down-regulation of the most prominently up-regulated group member, CXCL1/gro-alpha resulted in inhibition of cell viability, invasion and proliferation. In vivo, down-regulation of CXCL1 resulted in a nearly complete prevention of tumor growth in nude mice. Mechanistically, auto-regulatory mechanisms involving NF-kappaB and Akt appear to be involved in pro-tumorigenic functions of CXCL1. |
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| DOI: | doi:10.1016/j.cyto.2011.10.019 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1016/j.cyto.2011.10.019 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1043466611008064 |
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| | DOI: https://doi.org/10.1016/j.cyto.2011.10.019 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chemokines |
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| | Colorectal liver metastasis |
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| | CXCL1 |
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| | Nude mouse |
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| K10plus-PPN: | 1581320353 |
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| Verknüpfungen: | → Zeitschrift |
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Down-regulation of CXCL1 inhibits tumor growth in colorectal liver metastasis / Bandapalli, Obul Reddy [VerfasserIn]; 2012 (Online-Ressource)
