Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Berkel, Simone [VerfasserIn]   i
 Eltokhi, Ahmed [VerfasserIn]   i
 Fröhlich, Henning [VerfasserIn]   i
 Porras-Gonzalez, Diana [VerfasserIn]   i
 Rafiullah, Rafiullah [VerfasserIn]   i
 Sprengel, Rolf [VerfasserIn]   i
 Rappold, Gudrun [VerfasserIn]   i
Titel:Sex hormones regulate SHANK expression
Verf.angabe:Simone Berkel, Ahmed Eltokhi, Henning Fröhlich, Diana Porras-Gonzalez, Rafiullah Rafiullah, Rolf Sprengel and Gudrun A. Rappold
E-Jahr:2018
Jahr:25 September 2018
Umfang:10 S.
Fussnoten:Gesehen am 27.09.2018
Titel Quelle:Enthalten in: Frontiers in molecular neuroscience
Ort Quelle:Lausanne : Frontiers Research Foundation, 2008
Jahr Quelle:2018
Band/Heft Quelle:11(2018), Artikel-ID 337
ISSN Quelle:1662-5099
Abstract:Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4 : 1 for ASD and 11 : 1 for Asperger syndrome. Mutations in the SHANK genes (comprising SHANK1, SHANK2 and SHANK3), coding for postsynaptic scaffolding proteins, have been tightly associated with ASD. As early brain development is strongly influenced by sex hormones, we investigated the effect of dihydrotestosterone and 17β-estradiol on SHANK expression in a human neuroblastoma cell model. Both sex hormones had a significant impact on the expression of all three SHANK genes, which could be effectively blocked by androgen and estrogen receptor antagonists. In neuron-specific androgen receptor knock-out mice (ArNesCre), we found a nominal significant reduction of all Shank genes at postnatal day 7.5 in the cortex. In the developing cortex of wild-type CD1 mice, a sex-differential protein expression was identified for all Shanks at embryonic day 17.5 and postnatal day 7.5 with significantly higher protein levels in male compared to female pubs. Together, we could show that SHANK expression is influenced by sex hormones leading to a sex-differential expression, thus providing novel insights into the sex bias in ASD.
DOI:doi:10.3389/fnmol.2018.00337
URL:kostenfrei: Volltext: http://dx.doi.org/10.3389/fnmol.2018.00337
 kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fnmol.2018.00337/full
 DOI: https://doi.org/10.3389/fnmol.2018.00337
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:17ß-Estradiol
 androgen receptor knock-out mouse
 Autism spectrum disorders (ASD)
 Dihydrotestosterone
 sex differences
 SH-SY5Y cells
 shank
K10plus-PPN:1581383665
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68309643   QR-Code
zum Seitenanfang