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Verfasst von:Bandapalli, Obul Reddy [VerfasserIn]   i
 Macher-Göppinger, Stephan [VerfasserIn]   i
 Schirmacher, Peter [VerfasserIn]   i
 Brand, Karsten [VerfasserIn]   i
Titel:Paracrine signalling in colorectal liver metastases involving tumor cell-derived PDGF-C and hepatic stellate cell-derived PAK-2
Verf.angabe:Obul R. Bandapalli, Stephan Macher-Goeppinger, Peter Schirmacher, Karsten Brand
E-Jahr:2012
Jahr:24 February 2012
Umfang:9 S.
Fussnoten:Gesehen am 27.09.2018
Titel Quelle:Enthalten in: Clinical & experimental metastasis
Ort Quelle:Dordrecht : Springer Science + Business Media B.V., 1983
Jahr Quelle:2012
Band/Heft Quelle:29(2012), 5, Seite 409-417
ISSN Quelle:1573-7276
Abstract:In a nude mouse model of colorectal liver metastases, we have identified a paracrine tumor cell/host cell signalling pathway that is apparently required for successful tumor growth. Whereas recombinant platelet derived growth factor-C (PDGF-C) and supernatants from PDGF-C secreting wild type LS174T colon carcinoma cells could rescue tumor promoting hepatic stellate cells (HSC) from growth inhibition by serum starvation, supernatants from LS174T colon carcinoma cells with reduced secretion of PDGF-C had much less effect on serum starved HSC. Autocrine growth inhibition of LS174T cells by PDGF-C knock-down was only marginal. In vivo, a prominent inhibition of liver metastasis was observed if PDGF-C was knocked-down in LS174T cells. By whole genome array analysis of host cells of the invasion front and subsequent immunohistochemical staining we identified p21 activated kinase-2 (PAK-2) as being strongly and specifically expressed by HSC. The above described effect of PDGF-C on HSC was found to be dependent on PAK-2 because in contrast to wild type HSC, silencing of PAK-2 in HSC only allowed for a partial PDGF-C-mediated rescue from serum starvation leading to only a slight increase of proliferation. These data indicate that PDGF-C promotes tumor growth via a growth promoting effect on HSC that is at least in part dependent on the presence of functional PAK-2.
DOI:doi:10.1007/s10585-012-9459-3
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1007/s10585-012-9459-3
 Volltext: https://doi.org/10.1007/s10585-012-9459-3
 DOI: https://doi.org/10.1007/s10585-012-9459-3
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Colorectal liver metastasis
 HSC
 LS174T
 PAK2
 PDGFC
K10plus-PPN:1581356269
Verknüpfungen:→ Zeitschrift

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