Establishing a porcine model of small for size syndrome following liver resection

• Verfasst von: Golriz, Mohammad [VerfasserIn]
• Verfasst von: Ashrafi, Maryam [VerfasserIn]
• Verfasst von: Khajeh, Elias [VerfasserIn]
• Verfasst von: Majlesara, Ali [VerfasserIn]
• Verfasst von: Flechtenmacher, Christa [VerfasserIn]
• Verfasst von: Mehrabi, Arianeb [VerfasserIn]
• Titel: Establishing a porcine model of small for size syndrome following liver resection
• Verf.angabe: Mohammad Golriz, Maryam Ashrafi, Elias Khajeh, Ali Majlesara, Christa Flechtenmacher, and Arianeb Mehrabi
• E-Jahr: 2017
• Jahr: 29 August 2017
• Umfang: 8 S.
• Fussnoten: Gesehen am 27.09.2018
• Titel Quelle: Enthalten in: Canadian journal of gastroenterology & hepatology
• Ort Quelle: Oakville, Ontario : Pulsus Group, 2014
• Jahr Quelle: 2017
• Band/Heft Quelle: (2017), Artikel-ID 5127178, Seite 1-8
• ISSN Quelle: 2291-2797
• DOI: doi:10.1155/2017/5127178
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581356609

Abstract

Background. Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. Aim. The aim of this study was to establish a porcine model of SFSS. Methods. Twenty-four Landrace pigs underwent liver resection with a remnant liver volume of 50% (group A, ), 25% (group B, ), and 15% (group C, ). After resection, the animals were followed up for 8 days and clinical, laboratory, and histopathological outcomes were evaluated. Results. The survival rate was significantly lower in group C compared with the other groups (). The international normalized ratio, bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase levels increased shortly after surgery in groups B and C, but no change was observed in group A ( for all analyses). The histopathological findings in group A were mainly mild mitoses, in group B severe mitoses and hepatocyte ballooning, moderate congestion, and hemorrhage, along with mild necrosis, and in group C extended tissue damage with severe necrosis, hemorrhage, and congestion. Conclusions. Combination of clinical, laboratory, and histopathological evaluations is needed to confirm the diagnosis of SFSS. 75% liver resection in porcine model results in SFSS. 85% liver resection causes irreversible liver failure.