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Verfasst von:Golriz, Mohammad [VerfasserIn]   i
 Fonouni, Hamidreza [VerfasserIn]   i
 Kuttymuratov, Gani [VerfasserIn]   i
 Esmaeilzadeh, Majid [VerfasserIn]   i
 Tahmasbi Rad, Morva [VerfasserIn]   i
 Jarahian, Parvin [VerfasserIn]   i
 Longerich, Thomas [VerfasserIn]   i
 Faridar, Alireza [VerfasserIn]   i
 Abbasi Dezfouli, Sepehr [VerfasserIn]   i
 Mehrabi, Arianeb [VerfasserIn]   i
 Gebhard, Martha-Maria [VerfasserIn]   i
Titel:Influence of a modified preservation solution in kidney transplantation
Titelzusatz:A comparative experimental study in a porcine model
Verf.angabe:Mohammad Golriz, Hamidreza Fonouni, Gani Kuttymuratov, Majid Esmaeilzadeh, Morva Tahmasbi Rad, Parvin Jarahian, Thomas Longerich, Alireza Faridar, Sepehr Abbasi, Arianeb Mehrabi, Marta M. Gebhard
Jahr:2017
Umfang:10 S.
Fussnoten:Available online 1 September 2015 ; Gesehen am 27.09.2018
Titel Quelle:Enthalten in: Asian journal of surgery
Ort Quelle:Hong Kong : Excerpta Medica Asia, 2000
Jahr Quelle:2017
Band/Heft Quelle:40(2017), 2, Seite 106-115
ISSN Quelle:0219-3108
Abstract:Summary Background/Objective Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidine-tryptophane ketoglutarate (HTK-N) solution has been designed and its protective efficacy was compared with the standard preservation solutions—University of Wisconsin solution and standard HTK or Custodiol (Bretschneider's solution). Methods Seventy-two landrace pigs were included into the study, as donors and recipients. The donor kidneys were perfused during explantation with cold University of Wisconsin solution (n = 12), standard HTK (n = 12), or HTK-N solutions (n = 12), kept in the respective preservation solution at 4°C for 30 hours, implanted in the recipient pigs, and reperfused. The pigs survived in daily control for 7 days. The serum creatinine and blood urea nitrogen were assessed in pre- and postreperfusion phase on the 3rd day and 7th day posttransplantation. Additionally, tissue samples were taken to analyze the histopathological degree of tubular injury and regeneration before and after reperfusion. Results The three preservation groups were comparable in age, body weight, and hemodynamic parameters. According to statistical proof, they differed in none of the control parameters. Conclusion Although the new preservation HTK solution is in several points a well-thought-out modification of the standard HTK solution, its preservation efficacy, at least for kidney preservation in a pig model for 30 hours, seems to be comparable to the current used solutions. A real advantage, however, could be confirmed in clinical settings, where marginal organs may influence the clinical outcome.
DOI:doi:10.1016/j.asjsur.2015.07.001
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.asjsur.2015.07.001
 Volltext: http://www.sciencedirect.com/science/article/pii/S1015958415000846
 DOI: https://doi.org/10.1016/j.asjsur.2015.07.001
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ischemia reperfusion injury
 kidney transplantation
 preservation solution
K10plus-PPN:1581358113
Verknüpfungen:→ Zeitschrift

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